Monica Imperi, Giovanni Gherardi, Giovanna Alfarone, Roberta Creti
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Serotype III was the most frequent (n = 41, 38%), followed by type Ia and type V (n = 20 each, 18.5%). Serotypes Ia, Ib, II, III, IV, and V accounted for all but one isolates (99.1%). The iGBS isolates were universally susceptible to penicillin, while the prevalence of resistance to clindamycin, erythromycin, tetracycline, and high-level gentamicin resistance was 26.8%, 24.1%, 85.2%, and 5.5%, respectively, with the predominance of the erm(B) gene for macrolide resistance and the tet(M) gene for tetracycline resistance. The associations between the serotypes/antimicrobial resistance/virulence traits underlined the increasing importance of serotype III and its contribution to antimicrobial resistance as well as the steady increase over time of serotype IV. 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引用次数: 0
摘要
B 组链球菌(GBS,无乳链球菌)是一种在成人中日益重要的病原体。在 2015-2019 年期间,通过基于自愿的监测收集了非怀孕成人中的严重和侵袭性病例。共对 108 株 GBS 菌株进行了表型和基因型鉴定,包括血清型、抗菌药耐药性、纤毛、表面蛋白基因和超强毒性粘附素 hvgA。患者分为两个年龄组:成年人(18-64 岁;n = 32)和老年人(≥65 岁;n = 72)。平均年龄为 70.8 岁,男女比例为 1.7。大多数分离株是从菌血症病例(血液,n = 93)中回收的,老年人中发生侵袭性 GBS 感染(iGBS)的频率较高(66.7%)。血清 III 型最常见(41 人,38%),其次是 Ia 型和 V 型(各 20 人,18.5%)。血清型 Ia、Ib、II、III、IV 和 V 占了除一个分离株之外的所有分离株(99.1%)。iGBS 分离物对青霉素普遍敏感,而对克林霉素、红霉素、四环素和庆大霉素耐药的流行率分别为 26.8%、24.1%、85.2% 和 5.5%,对大环内酯类耐药的主要是 erm(B) 基因,对四环素耐药的主要是 tet(M) 基因。血清型/抗菌药耐药性/病毒性特征之间的关联凸显了血清型 III 的重要性及其对抗菌药耐药性的贡献,以及血清型 IV 随时间推移的稳步增长。这项全国性研究证实,有必要通过对 GBS 感染的持续监测来监测非孕期成人中的 GBS 流行病学。
Group B Streptococcus Infections in Non-Pregnant Adults, Italy, 2015–2019
Group B Streptococcus (GBS, Streptococcus agalactiae) is a pathogen of increasing importance in adults. Severe and invasive cases in non-pregnant adults were collected during the period 2015–2019 by voluntary-based surveillance. In total, 108 GBS strains were phenotypically and genotypically characterized for the serotype, antimicrobial resistance, pili, surface protein genes, and the hyper-virulent adhesin hvgA. Patients were divided into two age groups: adults (18–64 years; n = 32) and older adults (≥65 years; n = 72). The average age was 70.8 years, with a male/female ratio of 1.7. Most isolates were recovered from cases of bacteremia (blood, n = 93), and a higher frequency of invasive GBS infections (iGBS) was found among older adults (66.7%). Serotype III was the most frequent (n = 41, 38%), followed by type Ia and type V (n = 20 each, 18.5%). Serotypes Ia, Ib, II, III, IV, and V accounted for all but one isolates (99.1%). The iGBS isolates were universally susceptible to penicillin, while the prevalence of resistance to clindamycin, erythromycin, tetracycline, and high-level gentamicin resistance was 26.8%, 24.1%, 85.2%, and 5.5%, respectively, with the predominance of the erm(B) gene for macrolide resistance and the tet(M) gene for tetracycline resistance. The associations between the serotypes/antimicrobial resistance/virulence traits underlined the increasing importance of serotype III and its contribution to antimicrobial resistance as well as the steady increase over time of serotype IV. This nationwide study confirmed the need for monitoring the GBS epidemiology in non-pregnant adults through continuous surveillance of GBS infections.
期刊介绍:
Pathogens (ISSN 2076-0817) publishes reviews, regular research papers and short notes on all aspects of pathogens and pathogen-host interactions. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodical details must be provided for research articles.