基于磁共振成像模拟的经腹胎儿脉搏血氧仪敏感性分析。

IF 2.9 2区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Biomedical optics express Pub Date : 2024-08-19 DOI:10.1364/boe.531149

Jingyi Wu,Gopika Satish,Alexander Ruesch,Baptiste Jayet,Katarzyna Komolibus,Stefan Andersson-Engels,Martin P Debreczeny,Jana M Kainerstorfer

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引用次数: 0

摘要

经腹胎儿脉搏血氧仪为改善胎儿监护和减少不必要的干预提供了一种很有前景的方法。利用从孕妇核磁共振扫描中提取的真实三维几何图形，我们进行了光子模拟，以确定检测胎儿心率和氧饱和度的最佳源-检测器配置。我们的研究结果表明，使用大于 100 毫米的光源-探测器（SD）距离和介于 730 纳米和 850 纳米之间的波长，在深度达 30 毫米处测量胎儿信号在理论上是可行的。此外，我们还强调了根据胎儿位置和母体解剖结构定制 SD 配置的重要性。这些见解为加强临床应用中的无创胎儿监护铺平了道路。

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Sensitivity analysis of transabdominal fetal pulse oximetry using MRI-based simulations.

Transabdominal fetal pulse oximetry offers a promising approach to improve fetal monitoring and reduce unnecessary interventions. Utilizing realistic 3D geometries derived from MRI scans of pregnant women, we conducted photon simulations to determine optimal source-detector configurations for detecting fetal heart rate and oxygenation. Our findings demonstrate the theoretical feasibility of measuring fetal signals at depths up to 30 mm using source-detector (SD) distances greater than 100 mm and wavelengths between 730 and 850 nm. Furthermore, we highlight the importance of customizing SD configurations based on fetal position and maternal anatomy. These insights pave the way for enhanced non-invasive fetal monitoring in clinical application.

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来源期刊

Biomedical optics express BIOCHEMICAL RESEARCH METHODS-OPTICS

CiteScore

6.80

自引率

11.80%

发文量

633

审稿时长

1 months

期刊介绍： The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including: Tissue optics and spectroscopy Novel microscopies Optical coherence tomography Diffuse and fluorescence tomography Photoacoustic and multimodal imaging Molecular imaging and therapies Nanophotonic biosensing Optical biophysics/photobiology Microfluidic optical devices Vision research.