多酚类黄酮水飞蓟素包裹碳量子点(SL-CQDs)的合成、表征及其体外抗癌和抗菌潜力

IF 3.9 3区 化学 Q2 POLYMER SCIENCE
Madhankumar Somasundaram, Asmatanzeem Bepari, Syed Arif Hussain, Lina M. Alneghery, Mohammed Al-Zharani, Fahd A. Nasr, Ashraf Ahmed Qurtam, Paulpandi Manickam, Shaik Kalimulla Niazi
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引用次数: 0

摘要

本研究的目的是利用香蕉皮和水飞蓟素(SL-CQDs)生产碳量子点(CQDs),以提高其抗菌能力和在实验室条件下对人类乳腺癌(MCF-7)细胞的有效性。目前的研究旨在利用水热法从香蕉皮中合成高荧光碳点和活性炭,重点是降低成本和避免对环境造成影响。合成的碳量子点具有优异的生物相容性,可作为纳米载体提高多酚黄酮水飞蓟素的可及性。化疗药物对治疗侵袭性恶性肿瘤至关重要,但它们也有局限性,如缺乏选择性和产生多药耐药性,从而导致癌症扩散。尽管水飞蓟素具有良好的特性,但其水溶性差、吸附性和不稳定性等困难阻碍了水飞蓟素的临床研究。我们评估了 SL-CQDs 对铜绿假单胞菌和大肠杆菌等革兰氏阴性菌以及金黄色葡萄球菌和枯草杆菌等革兰氏阳性菌的抗菌效果。SL-CQDs 具有抗菌活性,最低抑菌浓度 (MIC) 为 2 µg/mL。当 SL-CQD 的 IC50 浓度为 18 µg/mL 时,MCF-7 细胞的活力下降。凋亡体的存在表明,水飞蓟素的引入诱导了一种特定形式的细胞死亡。SL-CQDs 具有显著的抗菌活性,并能有效抑制乳腺癌细胞的增殖。我们最近的分析表明,SL-CQDs 在有效治疗人类病原体和乳腺癌细胞方面具有潜在的优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Synthesis, Characterization of Polyphenolic Flavonoid Silymarin Encapsulated Carbon Quantum Dots (SL-CQDs) and Its Anticancer, Antibacterial Potential in In Vitro

Synthesis, Characterization of Polyphenolic Flavonoid Silymarin Encapsulated Carbon Quantum Dots (SL-CQDs) and Its Anticancer, Antibacterial Potential in In Vitro

The objective of this study is to produce carbon quantum dots (CQDs) by utilizing banana peels and including silymarin (SL-CQDs) to improve their antibacterial capabilities and effectiveness against Human breast cancer (MCF-7) cells under laboratory conditions. The current research aims to synthesize highly fluorescent carbon dots and activated carbon from banana peels using a hydrothermal method, with a focus on reducing costs and avoiding environmental consequences. Carbon quantum dots, which are synthesized, possess exceptional biocompatibility and can serve as nano-carriers to enhance the accessibility of Polyphenolic flavonoid silymarin. Chemotherapeutics are essential in treating aggressive malignancies, but they have limitations such as a lack of selectivity and the development of multidrug resistance, which can result in the spread of cancer. Despite its promising features, the clinical research of silymarin is hindered by difficulties such as poor water solubility, adsorption, and instability. The antimicrobial efficacy of SL-CQDs was assessed against gram-negative bacteria, including Pseudomonas aeruginosa and E. coli, as well as gram-positive bacteria, including Staphylococcus aureus and Bacillus subtilis. The SL-CQDs demonstrated antibacterial activity, with a minimum inhibitory concentration (MIC) of 2 µg/mL. When SL-CQDs were administered at an IC50 concentration of 18 µg/mL, the viability of MCF-7 cells decreased. The existence of apoptotic bodies suggests that the introduction of silymarin induces a specific form of cellular demise. SL-CQDs possess notable antibacterial activities and efficiently suppress the proliferation of breast cancer cells. Our recent analysis suggests that SL-CQDs have the potential to be advantageous in the effective therapeutic treatment of Human pathogens and breast cancer cells.

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来源期刊
CiteScore
8.30
自引率
7.50%
发文量
335
审稿时长
1.8 months
期刊介绍: Journal of Inorganic and Organometallic Polymers and Materials [JIOP or JIOPM] is a comprehensive resource for reports on the latest theoretical and experimental research. This bimonthly journal encompasses a broad range of synthetic and natural substances which contain main group, transition, and inner transition elements. The publication includes fully peer-reviewed original papers and shorter communications, as well as topical review papers that address the synthesis, characterization, evaluation, and phenomena of inorganic and organometallic polymers, materials, and supramolecular systems.
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