Madhankumar Somasundaram, Asmatanzeem Bepari, Syed Arif Hussain, Lina M. Alneghery, Mohammed Al-Zharani, Fahd A. Nasr, Ashraf Ahmed Qurtam, Paulpandi Manickam, Shaik Kalimulla Niazi
{"title":"多酚类黄酮水飞蓟素包裹碳量子点(SL-CQDs)的合成、表征及其体外抗癌和抗菌潜力","authors":"Madhankumar Somasundaram, Asmatanzeem Bepari, Syed Arif Hussain, Lina M. Alneghery, Mohammed Al-Zharani, Fahd A. Nasr, Ashraf Ahmed Qurtam, Paulpandi Manickam, Shaik Kalimulla Niazi","doi":"10.1007/s10904-024-03383-y","DOIUrl":null,"url":null,"abstract":"<p>The objective of this study is to produce carbon quantum dots (CQDs) by utilizing banana peels and including silymarin (SL-CQDs) to improve their antibacterial capabilities and effectiveness against Human breast cancer (MCF-7) cells under laboratory conditions. The current research aims to synthesize highly fluorescent carbon dots and activated carbon from banana peels using a hydrothermal method, with a focus on reducing costs and avoiding environmental consequences. Carbon quantum dots, which are synthesized, possess exceptional biocompatibility and can serve as nano-carriers to enhance the accessibility of Polyphenolic flavonoid silymarin. Chemotherapeutics are essential in treating aggressive malignancies, but they have limitations such as a lack of selectivity and the development of multidrug resistance, which can result in the spread of cancer. Despite its promising features, the clinical research of silymarin is hindered by difficulties such as poor water solubility, adsorption, and instability. The antimicrobial efficacy of SL-CQDs was assessed against gram-negative bacteria, including <i>Pseudomonas aeruginosa</i> and <i>E. coli</i>, as well as gram-positive bacteria, including <i>Staphylococcus aureus</i> and <i>Bacillus subtilis</i>. The SL-CQDs demonstrated antibacterial activity, with a minimum inhibitory concentration (MIC) of 2 µg/mL. When SL-CQDs were administered at an IC50 concentration of 18 µg/mL, the viability of MCF-7 cells decreased. The existence of apoptotic bodies suggests that the introduction of silymarin induces a specific form of cellular demise. SL-CQDs possess notable antibacterial activities and efficiently suppress the proliferation of breast cancer cells. Our recent analysis suggests that SL-CQDs have the potential to be advantageous in the effective therapeutic treatment of Human pathogens and breast cancer cells.</p>","PeriodicalId":639,"journal":{"name":"Journal of Inorganic and Organometallic Polymers and Materials","volume":null,"pages":null},"PeriodicalIF":3.9000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis, Characterization of Polyphenolic Flavonoid Silymarin Encapsulated Carbon Quantum Dots (SL-CQDs) and Its Anticancer, Antibacterial Potential in In Vitro\",\"authors\":\"Madhankumar Somasundaram, Asmatanzeem Bepari, Syed Arif Hussain, Lina M. Alneghery, Mohammed Al-Zharani, Fahd A. Nasr, Ashraf Ahmed Qurtam, Paulpandi Manickam, Shaik Kalimulla Niazi\",\"doi\":\"10.1007/s10904-024-03383-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The objective of this study is to produce carbon quantum dots (CQDs) by utilizing banana peels and including silymarin (SL-CQDs) to improve their antibacterial capabilities and effectiveness against Human breast cancer (MCF-7) cells under laboratory conditions. The current research aims to synthesize highly fluorescent carbon dots and activated carbon from banana peels using a hydrothermal method, with a focus on reducing costs and avoiding environmental consequences. Carbon quantum dots, which are synthesized, possess exceptional biocompatibility and can serve as nano-carriers to enhance the accessibility of Polyphenolic flavonoid silymarin. Chemotherapeutics are essential in treating aggressive malignancies, but they have limitations such as a lack of selectivity and the development of multidrug resistance, which can result in the spread of cancer. Despite its promising features, the clinical research of silymarin is hindered by difficulties such as poor water solubility, adsorption, and instability. The antimicrobial efficacy of SL-CQDs was assessed against gram-negative bacteria, including <i>Pseudomonas aeruginosa</i> and <i>E. coli</i>, as well as gram-positive bacteria, including <i>Staphylococcus aureus</i> and <i>Bacillus subtilis</i>. The SL-CQDs demonstrated antibacterial activity, with a minimum inhibitory concentration (MIC) of 2 µg/mL. When SL-CQDs were administered at an IC50 concentration of 18 µg/mL, the viability of MCF-7 cells decreased. The existence of apoptotic bodies suggests that the introduction of silymarin induces a specific form of cellular demise. SL-CQDs possess notable antibacterial activities and efficiently suppress the proliferation of breast cancer cells. 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Synthesis, Characterization of Polyphenolic Flavonoid Silymarin Encapsulated Carbon Quantum Dots (SL-CQDs) and Its Anticancer, Antibacterial Potential in In Vitro
The objective of this study is to produce carbon quantum dots (CQDs) by utilizing banana peels and including silymarin (SL-CQDs) to improve their antibacterial capabilities and effectiveness against Human breast cancer (MCF-7) cells under laboratory conditions. The current research aims to synthesize highly fluorescent carbon dots and activated carbon from banana peels using a hydrothermal method, with a focus on reducing costs and avoiding environmental consequences. Carbon quantum dots, which are synthesized, possess exceptional biocompatibility and can serve as nano-carriers to enhance the accessibility of Polyphenolic flavonoid silymarin. Chemotherapeutics are essential in treating aggressive malignancies, but they have limitations such as a lack of selectivity and the development of multidrug resistance, which can result in the spread of cancer. Despite its promising features, the clinical research of silymarin is hindered by difficulties such as poor water solubility, adsorption, and instability. The antimicrobial efficacy of SL-CQDs was assessed against gram-negative bacteria, including Pseudomonas aeruginosa and E. coli, as well as gram-positive bacteria, including Staphylococcus aureus and Bacillus subtilis. The SL-CQDs demonstrated antibacterial activity, with a minimum inhibitory concentration (MIC) of 2 µg/mL. When SL-CQDs were administered at an IC50 concentration of 18 µg/mL, the viability of MCF-7 cells decreased. The existence of apoptotic bodies suggests that the introduction of silymarin induces a specific form of cellular demise. SL-CQDs possess notable antibacterial activities and efficiently suppress the proliferation of breast cancer cells. Our recent analysis suggests that SL-CQDs have the potential to be advantageous in the effective therapeutic treatment of Human pathogens and breast cancer cells.
期刊介绍:
Journal of Inorganic and Organometallic Polymers and Materials [JIOP or JIOPM] is a comprehensive resource for reports on the latest theoretical and experimental research. This bimonthly journal encompasses a broad range of synthetic and natural substances which contain main group, transition, and inner transition elements. The publication includes fully peer-reviewed original papers and shorter communications, as well as topical review papers that address the synthesis, characterization, evaluation, and phenomena of inorganic and organometallic polymers, materials, and supramolecular systems.