降解组学定义了从人类膝关节骨关节炎软骨到匹配滑液的蛋白水解信息流，以及分泌蛋白酶 ADAMTS5、MMP13 和 CMA1 对关节软骨破坏的贡献

IF 7.2 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage Pub Date : 2024-09-16 DOI:10.1016/j.joca.2024.09.002

Sumit Bhutada, Anna Hoyle, Nicolas S. Piuzzi, Suneel S. Apte

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引用次数: 0

摘要

蛋白水解软骨细胞外基质分解是骨关节炎（OA）发病机制中关节软骨损失的主要机制。我们试图确定匹配的膝关节OA软骨和滑膜液中的蛋白水解肽在整个蛋白质组范围内的重叠情况，以增加前瞻性生物标志物库，并将蛋白水解裂解归因于特定的分泌蛋白酶。

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Degradomics defines proteolysis information flow from human knee osteoarthritis cartilage to matched synovial fluid and the contributions of secreted proteases ADAMTS5, MMP13 and CMA1 to articular cartilage breakdown

Proteolytic cartilage extracellular matrix breakdown is a major mechanism of articular cartilage loss in osteoarthritis (OA) pathogenesis. We sought to determine the overlap of proteolytic peptides in matched knee OA cartilage and synovial fluid on a proteome-wide scale to increase the prospective biomarker repertoire and to attribute proteolytic cleavages to specific secreted proteases.

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来源期刊

Osteoarthritis and Cartilage 医学-风湿病学

CiteScore

11.70

自引率

7.10%

发文量

802

审稿时长

52 days

期刊介绍： Osteoarthritis and Cartilage is the official journal of the Osteoarthritis Research Society International. It is an international, multidisciplinary journal that disseminates information for the many kinds of specialists and practitioners concerned with osteoarthritis.