{"title":"RAFT 聚合辅助 P(NIPAm-co-AAc)-AEMR 集成 PVA 水凝胶：双重响应特性、质地分析和细胞毒性研究","authors":"","doi":"10.1016/j.reactfunctpolym.2024.106052","DOIUrl":null,"url":null,"abstract":"<div><p>Modified P(NIPAm-co-AAc) copolymers are prepared using Radical Addition Fragmentation Chain Transfer (RAFT) copolymerization by varying the concentration of castor oil sourced acrylated epoxy methyl ricinoleate (AEMR). Subsequently, hydrogels are prepared by integrating copolymers with polyvinyl alcohol (PVA) via freeze-thaw process. The employment of RAFT polymerization yielded copolymers with dispersity (D) value of 1.2–1.3 revealing the formation of structurally well controlled polymer chains. The lower critical solution temperature (LCST) of the copolymers (∼30–35 °C) are tuned to the range of physiological temperature (∼37 °C) in PVA hydrogel system. Temperature dependent viscoelastic properties indicated that the characteristics of copolymeric solutions and hydrogels are composition dependent while undergoing noncovalent interactions and the conformational changes and the samples showed extremely elastic behaviour beyond LCST. Swelling ratio of hydrogels are also found to be pH dependent, which displayed higher swelling ratio in alkaline and reduced swelling ratio in acidic medium. Cytotoxicity studies with L929 cells showed that the copolymers and hydrogels exhibited desirable biocompatibility, which gets improved with AEMR concentrations. Thus, these dual responsive PA-AEMR-PVA smart hydrogels can be used as a viable functional material for possible bio-medical applications.</p></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":null,"pages":null},"PeriodicalIF":4.5000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"RAFT polymerization assisted P(NIPAm-co-AAc)-AEMR integrated PVA hydrogels: Dual responsive features, texture analysis, and cytotoxicity studies\",\"authors\":\"\",\"doi\":\"10.1016/j.reactfunctpolym.2024.106052\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Modified P(NIPAm-co-AAc) copolymers are prepared using Radical Addition Fragmentation Chain Transfer (RAFT) copolymerization by varying the concentration of castor oil sourced acrylated epoxy methyl ricinoleate (AEMR). Subsequently, hydrogels are prepared by integrating copolymers with polyvinyl alcohol (PVA) via freeze-thaw process. The employment of RAFT polymerization yielded copolymers with dispersity (D) value of 1.2–1.3 revealing the formation of structurally well controlled polymer chains. The lower critical solution temperature (LCST) of the copolymers (∼30–35 °C) are tuned to the range of physiological temperature (∼37 °C) in PVA hydrogel system. Temperature dependent viscoelastic properties indicated that the characteristics of copolymeric solutions and hydrogels are composition dependent while undergoing noncovalent interactions and the conformational changes and the samples showed extremely elastic behaviour beyond LCST. Swelling ratio of hydrogels are also found to be pH dependent, which displayed higher swelling ratio in alkaline and reduced swelling ratio in acidic medium. Cytotoxicity studies with L929 cells showed that the copolymers and hydrogels exhibited desirable biocompatibility, which gets improved with AEMR concentrations. Thus, these dual responsive PA-AEMR-PVA smart hydrogels can be used as a viable functional material for possible bio-medical applications.</p></div>\",\"PeriodicalId\":20916,\"journal\":{\"name\":\"Reactive & Functional Polymers\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2024-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reactive & Functional Polymers\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S138151482400227X\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reactive & Functional Polymers","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S138151482400227X","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Modified P(NIPAm-co-AAc) copolymers are prepared using Radical Addition Fragmentation Chain Transfer (RAFT) copolymerization by varying the concentration of castor oil sourced acrylated epoxy methyl ricinoleate (AEMR). Subsequently, hydrogels are prepared by integrating copolymers with polyvinyl alcohol (PVA) via freeze-thaw process. The employment of RAFT polymerization yielded copolymers with dispersity (D) value of 1.2–1.3 revealing the formation of structurally well controlled polymer chains. The lower critical solution temperature (LCST) of the copolymers (∼30–35 °C) are tuned to the range of physiological temperature (∼37 °C) in PVA hydrogel system. Temperature dependent viscoelastic properties indicated that the characteristics of copolymeric solutions and hydrogels are composition dependent while undergoing noncovalent interactions and the conformational changes and the samples showed extremely elastic behaviour beyond LCST. Swelling ratio of hydrogels are also found to be pH dependent, which displayed higher swelling ratio in alkaline and reduced swelling ratio in acidic medium. Cytotoxicity studies with L929 cells showed that the copolymers and hydrogels exhibited desirable biocompatibility, which gets improved with AEMR concentrations. Thus, these dual responsive PA-AEMR-PVA smart hydrogels can be used as a viable functional material for possible bio-medical applications.
期刊介绍：
Reactive & Functional Polymers provides a forum to disseminate original ideas, concepts and developments in the science and technology of polymers with functional groups, which impart specific chemical reactivity or physical, chemical, structural, biological, and pharmacological functionality. The scope covers organic polymers, acting for instance as reagents, catalysts, templates, ion-exchangers, selective sorbents, chelating or antimicrobial agents, drug carriers, sensors, membranes, and hydrogels. This also includes reactive cross-linkable prepolymers and high-performance thermosetting polymers, natural or degradable polymers, conducting polymers, and porous polymers.
Original research articles must contain thorough molecular and material characterization data on synthesis of the above polymers in combination with their applications. Applications include but are not limited to catalysis, water or effluent treatment, separations and recovery, electronics and information storage, energy conversion, encapsulation, or adhesion.
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