乳腺癌治疗的进展:纳米铜粒子的前景

IF 3.6 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
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引用次数: 0

摘要

背景乳腺癌(BC)是全球妇女发病率最高的癌症,给治疗带来了巨大挑战。本综述旨在探讨纳米铜粒子(CuNPs)通过靶向给药、改善成像及其抗血管生成特性来增强乳腺癌治疗的潜力。方法本综述综合了现有关于纳米铜粒子在乳腺癌治疗中疗效的文献,探讨了纳米技术中常见的挑战,如纳米粒子的毒性、可扩展性和监管障碍。结果表明,CuNPs 能够选择性地靶向癌细胞,同时保护健康组织,从而提高疗效。其独特的物理化学特性促进了高效的生物分布并增强了成像能力。此外,CuNPs 还具有抗血管生成活性,可以通过阻止新血管的形成来抑制肿瘤生长。通过探讨当前疗法的局限性并提出创新解决方案,本综述为纳米技术在肿瘤学领域的未来发展提供了宝贵的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advancements in breast cancer therapy: The promise of copper nanoparticles

Background

Breast cancer (BC) is the most prevalent cancer among women worldwide and poses significant treatment challenges. Traditional therapies often lead to adverse side effects and resistance, necessitating innovative approaches for effective management.

Objective

This review aims to explore the potential of copper nanoparticles (CuNPs) in enhancing breast cancer therapy through targeted drug delivery, improved imaging, and their antiangiogenic properties.

Methods

The review synthesizes existing literature on the efficacy of CuNPs in breast cancer treatment, addressing common challenges in nanotechnology, such as nanoparticle toxicity, scalability, and regulatory hurdles. It proposes a novel hybrid method that combines CuNPs with existing therapeutic modalities to optimize treatment outcomes.

Results

CuNPs demonstrate the ability to selectively target cancer cells while sparing healthy tissues, leading to improved therapeutic efficacy. Their unique physicochemical properties facilitate efficient biodistribution and enhanced imaging capabilities. Additionally, CuNPs exhibit antiangiogenic activity, which can inhibit tumor growth by preventing the formation of new blood vessels.

Conclusion

The findings suggest that CuNPs represent a promising avenue for advancing breast cancer treatment. By addressing the limitations of current therapies and proposing innovative solutions, this review contributes valuable insights into the future of nanotechnology in oncology.

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来源期刊
CiteScore
6.60
自引率
2.90%
发文量
202
审稿时长
85 days
期刊介绍: The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.
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