James Oyim , Aviwe Magadla , John Mack , Edith Amuhaya , Tebello Nyokong
{"title":"拓展光动力疗法的视野：铟金属化吡啶基反式-A2B2卟啉作为新型抗生物膜剂","authors":"James Oyim , Aviwe Magadla , John Mack , Edith Amuhaya , Tebello Nyokong","doi":"10.1016/j.dyepig.2024.112448","DOIUrl":null,"url":null,"abstract":"<div><p>Modern medicine is exploring new approaches to combat bacterial infections associated with antibiotic-resistant bacteria and biofilms. Among these, antimicrobial photodynamic therapy (aPDT) stands out for its ability to target pathogenic microbes effectively. In this study, we investigated the antimicrobial potential of the newly synthesized indium metalated pyridinyl-based <em>trans</em>-A<sub>2</sub>B<sub>2</sub> porphyrin complexes, <strong>1a,b</strong> and <strong>2a</strong>,<strong>b</strong>. The dicationic porphyrins, <strong>1b</strong> and <strong>2b,</strong> exhibited remarkable aPDT efficacy against both <em>S. aureus</em> and <em>E. coli</em> planktonic forms. Further investigation into the antimicrobial effects of the cationic porphyrins against <em>E. coli</em> and <em>S. aureus</em> biofilms revealed that both complexes (<strong>1b</strong> and <strong>2b</strong>) exhibited high efficacy in aPDT attributed to <em>tert</em>-butyl and thiophene groups that enhance photo-physicochemical properties and bacterial membrane accumulation. Scanning electron microscopy (SEM) showed disruption of cell membranes following light exposure. Our work highlights the potential of aPDT as an effective strategy for managing biofilms. By harnessing the power of these innovative compounds, we contribute to the ongoing battle against microbial threats.</p></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"232 ","pages":"Article 112448"},"PeriodicalIF":4.1000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Expanding the horizons of photodynamic therapy: Indium metalated pyridinyl-based trans-A2B2 porphyrin as novel anti-biofilm agents\",\"authors\":\"James Oyim , Aviwe Magadla , John Mack , Edith Amuhaya , Tebello Nyokong\",\"doi\":\"10.1016/j.dyepig.2024.112448\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Modern medicine is exploring new approaches to combat bacterial infections associated with antibiotic-resistant bacteria and biofilms. Among these, antimicrobial photodynamic therapy (aPDT) stands out for its ability to target pathogenic microbes effectively. In this study, we investigated the antimicrobial potential of the newly synthesized indium metalated pyridinyl-based <em>trans</em>-A<sub>2</sub>B<sub>2</sub> porphyrin complexes, <strong>1a,b</strong> and <strong>2a</strong>,<strong>b</strong>. The dicationic porphyrins, <strong>1b</strong> and <strong>2b,</strong> exhibited remarkable aPDT efficacy against both <em>S. aureus</em> and <em>E. coli</em> planktonic forms. Further investigation into the antimicrobial effects of the cationic porphyrins against <em>E. coli</em> and <em>S. aureus</em> biofilms revealed that both complexes (<strong>1b</strong> and <strong>2b</strong>) exhibited high efficacy in aPDT attributed to <em>tert</em>-butyl and thiophene groups that enhance photo-physicochemical properties and bacterial membrane accumulation. Scanning electron microscopy (SEM) showed disruption of cell membranes following light exposure. Our work highlights the potential of aPDT as an effective strategy for managing biofilms. By harnessing the power of these innovative compounds, we contribute to the ongoing battle against microbial threats.</p></div>\",\"PeriodicalId\":302,\"journal\":{\"name\":\"Dyes and Pigments\",\"volume\":\"232 \",\"pages\":\"Article 112448\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-09-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dyes and Pigments\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S014372082400514X\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dyes and Pigments","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S014372082400514X","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Expanding the horizons of photodynamic therapy: Indium metalated pyridinyl-based trans-A2B2 porphyrin as novel anti-biofilm agents
Modern medicine is exploring new approaches to combat bacterial infections associated with antibiotic-resistant bacteria and biofilms. Among these, antimicrobial photodynamic therapy (aPDT) stands out for its ability to target pathogenic microbes effectively. In this study, we investigated the antimicrobial potential of the newly synthesized indium metalated pyridinyl-based trans-A2B2 porphyrin complexes, 1a,b and 2a,b. The dicationic porphyrins, 1b and 2b, exhibited remarkable aPDT efficacy against both S. aureus and E. coli planktonic forms. Further investigation into the antimicrobial effects of the cationic porphyrins against E. coli and S. aureus biofilms revealed that both complexes (1b and 2b) exhibited high efficacy in aPDT attributed to tert-butyl and thiophene groups that enhance photo-physicochemical properties and bacterial membrane accumulation. Scanning electron microscopy (SEM) showed disruption of cell membranes following light exposure. Our work highlights the potential of aPDT as an effective strategy for managing biofilms. By harnessing the power of these innovative compounds, we contribute to the ongoing battle against microbial threats.
期刊介绍：
Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied.
Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media.
The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.
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