Magdalena Matczuk , Lena Ruzik , Andrei R. Timerbaev
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Recent development of CE-ICP-MS in biospeciation research and analysis: From anticancer drugs to nanoparticles and beyond
Capillary electrophoresis (CE) coupled to ICP-MS occupies its rightful place in mainstream biospeciation analysis, where this coupling is certainly much more than a complementary tool to the other separation-based techniques. This brief review critically discusses the current and emerging capabilities of CE-ICP-MS in the simultaneous detection of chemical species of a given element occurring in samples of biological origin, with a particular focus placed on the areas of metal-based drug and nanoparticle research. The most advantageous separation and detection strategies and the method's analytical performance are illustrated with a selection of real-world applications from recent literature. Among the methodological trends, using tandem and single-particle ICP-MS technology steadily moves to the frontline. Further progress in the field would keep step with more reliable, versatile, and robust CE-ICP-MS assays suitable for routine use.
期刊介绍：
TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.
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