{"title":"重新审视药用植物的植物化学成分在治疗 COVID-19 中的应用和疗效","authors":"Sahar Naveed , Abiodun Oladipo , Peter Olusakin Oladoye , Mahak Naveed , Mohammed Kadhom , Adewale Akanni Tella Taleat , Naveed Anjum","doi":"10.1016/j.prenap.2024.100087","DOIUrl":null,"url":null,"abstract":"<div><p>The paucity of targeted medications and vaccines, coupled with the coronaviruses (COVID-19) outbreak brought by SARS-CoV-19, forced scientists to look for novel antiviral formulations. The absence of a specific treatment for COVID-19, designing new drugs and considering the use of plant-based products is crucial in the search for an effective remedy to target this deadly virus. Phytochemical medicines are faster and more cost-effective compared to conventional treatment methods. The potential use of plant extracts in the prevention and treatment of COVID-19 may have its start with the abundance of naturally occurring chemicals obtained from plants. Coronavirus enzymes, which are necessary for virus infection and replication, can be inhibited by antiviral polyphenolic medications. Flavonoids, alkaloids, terpenes and terpenoids and many more are categorized as naturally occurring compounds that may be important in the development of antiviral treatments that block viral proteases. In this review, we presented up-to-date studies with special attention on challenges and side effects of medication and traditional plant-based therapies for respiratory problems. It also highlights the importance of plant-based antiviral compounds, particularly in the development of a broad-spectrum medication against coronaviruses like SARS-CoV-2.</p></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100087"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Revisiting the application and efficacy of phytochemicals of medicinal plants for the treatment of COVID-19\",\"authors\":\"Sahar Naveed , Abiodun Oladipo , Peter Olusakin Oladoye , Mahak Naveed , Mohammed Kadhom , Adewale Akanni Tella Taleat , Naveed Anjum\",\"doi\":\"10.1016/j.prenap.2024.100087\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The paucity of targeted medications and vaccines, coupled with the coronaviruses (COVID-19) outbreak brought by SARS-CoV-19, forced scientists to look for novel antiviral formulations. The absence of a specific treatment for COVID-19, designing new drugs and considering the use of plant-based products is crucial in the search for an effective remedy to target this deadly virus. Phytochemical medicines are faster and more cost-effective compared to conventional treatment methods. The potential use of plant extracts in the prevention and treatment of COVID-19 may have its start with the abundance of naturally occurring chemicals obtained from plants. Coronavirus enzymes, which are necessary for virus infection and replication, can be inhibited by antiviral polyphenolic medications. Flavonoids, alkaloids, terpenes and terpenoids and many more are categorized as naturally occurring compounds that may be important in the development of antiviral treatments that block viral proteases. In this review, we presented up-to-date studies with special attention on challenges and side effects of medication and traditional plant-based therapies for respiratory problems. It also highlights the importance of plant-based antiviral compounds, particularly in the development of a broad-spectrum medication against coronaviruses like SARS-CoV-2.</p></div>\",\"PeriodicalId\":101014,\"journal\":{\"name\":\"Pharmacological Research - Natural Products\",\"volume\":\"5 \",\"pages\":\"Article 100087\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Natural Products\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950199724000752\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950199724000752","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Revisiting the application and efficacy of phytochemicals of medicinal plants for the treatment of COVID-19
The paucity of targeted medications and vaccines, coupled with the coronaviruses (COVID-19) outbreak brought by SARS-CoV-19, forced scientists to look for novel antiviral formulations. The absence of a specific treatment for COVID-19, designing new drugs and considering the use of plant-based products is crucial in the search for an effective remedy to target this deadly virus. Phytochemical medicines are faster and more cost-effective compared to conventional treatment methods. The potential use of plant extracts in the prevention and treatment of COVID-19 may have its start with the abundance of naturally occurring chemicals obtained from plants. Coronavirus enzymes, which are necessary for virus infection and replication, can be inhibited by antiviral polyphenolic medications. Flavonoids, alkaloids, terpenes and terpenoids and many more are categorized as naturally occurring compounds that may be important in the development of antiviral treatments that block viral proteases. In this review, we presented up-to-date studies with special attention on challenges and side effects of medication and traditional plant-based therapies for respiratory problems. It also highlights the importance of plant-based antiviral compounds, particularly in the development of a broad-spectrum medication against coronaviruses like SARS-CoV-2.