细胞外植物-病原体界面的新结构见解

IF 8.3 2区 生物学 Q1 PLANT SCIENCES
Brian Críostóir Mooney, Renier A.L. van der Hoorn
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引用次数: 0

摘要

植物病原体对全球农业和粮食安全构成严重威胁,尤其是在气候变化和农用化学品使用减少的压力下。大多数植物病原体最初定殖于细胞外空间或细胞凋亡体,了解在此发生的宿主与病原体之间的相互作用对于在作物中设计可持续的抗病性至关重要。结构生物学在阐明植物与病原体相互作用的分子机制方面发挥了重要作用,但只有少数研究报告了细胞外复合物的结构。本文通过描述从已解决的 CERK1-几丁质、FLS2-flg22-BAK1、RXEG1-XEG1-BAK1 和 PGIP2-FpPG 复合物结构中获得的启示,重点介绍了这些已解决的胞外复合物。最后,我们讨论了基于人工智能的结构预测平台(如 AlphaFold)作为另一种假设生成器的潜力,以快速推进我们对植物病理学的分子认识,并开发新的战略来提高作物的抗病能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Novel structural insights at the extracellular plant-pathogen interface

Plant pathogens represent a critical threat to global agriculture and food security, particularly under the pressures of climate change and reduced agrochemical use. Most plant pathogens initially colonize the extracellular space or apoplast and understanding the host–pathogen interactions that occur here is vital for engineering sustainable disease resistance in crops. Structural biology has played important roles in elucidating molecular mechanisms underpinning plant-pathogen interactions but only few studies have reported structures of extracellular complexes. This article highlights these resolved extracellular complexes by describing the insights gained from the solved structures of complexes consisting of CERK1-chitin, FLS2-flg22-BAK1, RXEG1-XEG1-BAK1 and PGIP2-FpPG. Finally, we discuss the potential of AI-based structure prediction platforms like AlphaFold as an alternative hypothesis generator to rapidly advance our molecular understanding of plant pathology and develop novel strategies to increase crop resilience against disease.

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来源期刊
Current opinion in plant biology
Current opinion in plant biology 生物-植物科学
CiteScore
16.30
自引率
3.20%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.
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