家庭动态对癌症进展和患者预后的影响:情感和心理支持分析

IF 0.5 Q4 GENETICS & HEREDITY
Hashim Talib Hashim , Ali Talib Hashim , Ali Mahdi Mansour , Hossam Tharwat Ali , Narjiss Aji , Maryam Chichah , Mrinmoy Kundu , Amasee Falah Jabbar
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引用次数: 0

摘要

背景癌症是一组因细胞生长失控和异常细胞扩散而导致的疾病。在分子水平上,致癌基因、抑癌基因和 microRNA 基因的改变会导致癌症。这些基因的改变通常发生在体细胞水平,如果它们发生种系突变,就会导致遗传性或家族性癌症。材料/方法 这是一项横断面研究,旨在找出遗传关系(基因)与癌症的发展、症状严重程度和预后之间是否存在任何关系。本研究在 2022 年 1 月至 2022 年 8 月期间进行,共有 1998 名参与者。结果参与者的相对症状严重程度和改善程度的分布在统计学上存在差异,这取决于他们在这些人身上停留的时间长短。在与患病亲属症状严重程度相同的参与者群体中,停留时间最长的是几天,其次是几周。结论癌症家族史一直被流行病学家用作遗传易感性的代表。然而,共同的环境和相似的生活方式也可能导致同一家族中出现多种癌症。基因的交流在癌症的家族传播中起到了一定的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of family dynamics on cancer progression and patient outcomes: An analysis of emotional and psychological support

Background

Cancer is a group of diseases that results from the growth of cells in an uncontrolled way, and in addition spreading of abnormal cells. At the molecular level, Alterations of oncogenes, tumor-suppresser genes, and microRNA genes cause cancer. These alterations of genes usually occur at the somatic level, if they occur as germline mutations, they can cause heritable or familial cancer.

Materials/methods

This is a cross-sectional study which aims to find if there is any relationship between genetic relationship (genes) and cancer development, symptoms severity and prognosis. This study was conducted during the period of January 2022 and August 2022, and consisted of 1998 participants.

Results

There was a statistical difference in the distribution of participants' relative symptoms severity and improvement based on the duration they stayed with those people. Staying for days followed by weeks was the most reported in the group of participants with the same symptoms' severity of the diseased relative. On the opposite side, a longer duration of years was the predominant for worse symptoms of the family members despite the improvement of the patient.

Conclusions

Family history of cancer has been used by epidemiologists as a proxy for a genetically determined predisposition. However, a shared environment and similar lifestyles can also lead to multiple cancers in the same family. Genes' communication has a role in spreading the cancer among families.

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来源期刊
Human Gene
Human Gene Biochemistry, Genetics and Molecular Biology (General), Genetics
CiteScore
1.60
自引率
0.00%
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审稿时长
54 days
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