{"title":"评估肥胖和非肥胖患者的维生素 D 状态：病例对照研究","authors":"Salma Derbel , Lamiae Zarraa , Imane Assarrar , Nisrine Bouichrat , Siham Rouf , Hanane Latrech","doi":"10.1016/j.deman.2024.100237","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Vitamin D is an essential component of healthy bones and its deficiency is widespread in obese patients. Through our study, we aimed to look into vitamin D status in obese and non-obese patients and determine its association with hypertension, glucose levels, and lipid profiles.</p></div><div><h3>Patients and methods</h3><p>A case-control study was laid out to compare serum Vitamin D levels between obese patients and controls. Obese patients (<em>n</em>= 67) over 18 years old were recruited from our Endocrinology-Diabetology and Nutrition department between March 2018 and September 2023. Controls (<em>n</em> = 60) were randomly assigned and were matched for age, sex, glycated hemoglobin, ethnicity, and geographic area. The levels of Vitamin D in the serum were determined in obese patients and non-obese controls.</p></div><div><h3>Results</h3><p>Average serum Vitamin D concentration was established in both groups, reaching 10,41±4,2 ng/ml in obese patients and 15,14±6,1 ng/ml in the control group. The mean serum Vitamin D was significantly lower in the obese group (<em>p</em> = 0,000). A positive correlation was noticed between body fat and serum Vitamin D (<em>p</em> < 0,05). A significant correlation between vitamin D status and glycated hemoglobin in the obese group (<em>p</em> = 0,047) was found, whereas it was insignificant in the control group (<em>p</em> = 0,966). In addition, the correlation between vitamin D, blood pressure, and body mass index was significant (<em>p</em> <em>=</em> 0.004) as well as between vitamin D and triglycerides (<em>p</em> <em>=</em> 0.015) and cholesterol (<em>p</em> <em>=</em> 0.014).</p></div><div><h3>Conclusion</h3><p>Vitamin D deficiency is common in obese patients, as highlighted by our study, which is in line with other findings. This may be explained by the fact that vitamin D must be supplied at a greater volume in obese patients. A significant correlation between BMI, vitamin D, glycated hemoglobin, blood pressure, triglycerides, and total cholesterol was found. The pathophysiology behind this association is complex. Further research is needed to clarify the relationship between vitamin D, adipose tissue, and the other components of metabolic syndrome.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000416/pdfft?md5=6312261234fdc2e5e815735d8c34c4e9&pid=1-s2.0-S2666970624000416-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Assessment of vitamin D status in obese and non-obese patients: A case-control study\",\"authors\":\"Salma Derbel , Lamiae Zarraa , Imane Assarrar , Nisrine Bouichrat , Siham Rouf , Hanane Latrech\",\"doi\":\"10.1016/j.deman.2024.100237\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Vitamin D is an essential component of healthy bones and its deficiency is widespread in obese patients. Through our study, we aimed to look into vitamin D status in obese and non-obese patients and determine its association with hypertension, glucose levels, and lipid profiles.</p></div><div><h3>Patients and methods</h3><p>A case-control study was laid out to compare serum Vitamin D levels between obese patients and controls. Obese patients (<em>n</em>= 67) over 18 years old were recruited from our Endocrinology-Diabetology and Nutrition department between March 2018 and September 2023. Controls (<em>n</em> = 60) were randomly assigned and were matched for age, sex, glycated hemoglobin, ethnicity, and geographic area. The levels of Vitamin D in the serum were determined in obese patients and non-obese controls.</p></div><div><h3>Results</h3><p>Average serum Vitamin D concentration was established in both groups, reaching 10,41±4,2 ng/ml in obese patients and 15,14±6,1 ng/ml in the control group. The mean serum Vitamin D was significantly lower in the obese group (<em>p</em> = 0,000). A positive correlation was noticed between body fat and serum Vitamin D (<em>p</em> < 0,05). A significant correlation between vitamin D status and glycated hemoglobin in the obese group (<em>p</em> = 0,047) was found, whereas it was insignificant in the control group (<em>p</em> = 0,966). In addition, the correlation between vitamin D, blood pressure, and body mass index was significant (<em>p</em> <em>=</em> 0.004) as well as between vitamin D and triglycerides (<em>p</em> <em>=</em> 0.015) and cholesterol (<em>p</em> <em>=</em> 0.014).</p></div><div><h3>Conclusion</h3><p>Vitamin D deficiency is common in obese patients, as highlighted by our study, which is in line with other findings. This may be explained by the fact that vitamin D must be supplied at a greater volume in obese patients. A significant correlation between BMI, vitamin D, glycated hemoglobin, blood pressure, triglycerides, and total cholesterol was found. The pathophysiology behind this association is complex. Further research is needed to clarify the relationship between vitamin D, adipose tissue, and the other components of metabolic syndrome.</p></div>\",\"PeriodicalId\":72796,\"journal\":{\"name\":\"Diabetes epidemiology and management\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666970624000416/pdfft?md5=6312261234fdc2e5e815735d8c34c4e9&pid=1-s2.0-S2666970624000416-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diabetes epidemiology and management\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666970624000416\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes epidemiology and management","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666970624000416","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
摘要
背景维生素 D 是健康骨骼的重要组成部分，肥胖患者普遍缺乏维生素 D。我们的研究旨在调查肥胖和非肥胖患者的维生素 D 状态，并确定其与高血压、血糖水平和血脂状况的关系。患者和方法我们开展了一项病例对照研究，以比较肥胖患者和对照组的血清维生素 D 水平。2018年3月至2023年9月期间，本院内分泌科-糖尿病与营养科招募了18岁以上的肥胖患者（n=67）。对照组（n=60）为随机分配，在年龄、性别、糖化血红蛋白、种族和地理区域方面均匹配。测定了肥胖患者和非肥胖对照组血清中维生素 D 的水平。结果两组患者的平均血清维生素 D 浓度均为 10,41±4,2 纳克/毫升（肥胖患者）和 15,14±6,1 纳克/毫升（对照组）。肥胖组的血清维生素 D 平均值明显较低（p = 0,000）。体脂与血清维生素 D 之间呈正相关（p < 0,05）。肥胖组的维生素 D 状态与糖化血红蛋白之间存在明显的相关性（p = 0,047），而对照组的相关性不明显（p = 0,966）。此外，维生素 D、血压和体重指数之间的相关性显著（p = 0.004），维生素 D 与甘油三酯（p = 0.015）和胆固醇（p = 0.014）之间的相关性也显著。这可能是因为肥胖患者必须摄入更多的维生素 D。研究发现，体重指数、维生素 D、糖化血红蛋白、血压、甘油三酯和总胆固醇之间存在明显的相关性。这种关联背后的病理生理学非常复杂。还需要进一步的研究来阐明维生素 D、脂肪组织和代谢综合征其他成分之间的关系。
Assessment of vitamin D status in obese and non-obese patients: A case-control study
Background
Vitamin D is an essential component of healthy bones and its deficiency is widespread in obese patients. Through our study, we aimed to look into vitamin D status in obese and non-obese patients and determine its association with hypertension, glucose levels, and lipid profiles.
Patients and methods
A case-control study was laid out to compare serum Vitamin D levels between obese patients and controls. Obese patients (n= 67) over 18 years old were recruited from our Endocrinology-Diabetology and Nutrition department between March 2018 and September 2023. Controls (n = 60) were randomly assigned and were matched for age, sex, glycated hemoglobin, ethnicity, and geographic area. The levels of Vitamin D in the serum were determined in obese patients and non-obese controls.
Results
Average serum Vitamin D concentration was established in both groups, reaching 10,41±4,2 ng/ml in obese patients and 15,14±6,1 ng/ml in the control group. The mean serum Vitamin D was significantly lower in the obese group (p = 0,000). A positive correlation was noticed between body fat and serum Vitamin D (p < 0,05). A significant correlation between vitamin D status and glycated hemoglobin in the obese group (p = 0,047) was found, whereas it was insignificant in the control group (p = 0,966). In addition, the correlation between vitamin D, blood pressure, and body mass index was significant (p= 0.004) as well as between vitamin D and triglycerides (p= 0.015) and cholesterol (p= 0.014).
Conclusion
Vitamin D deficiency is common in obese patients, as highlighted by our study, which is in line with other findings. This may be explained by the fact that vitamin D must be supplied at a greater volume in obese patients. A significant correlation between BMI, vitamin D, glycated hemoglobin, blood pressure, triglycerides, and total cholesterol was found. The pathophysiology behind this association is complex. Further research is needed to clarify the relationship between vitamin D, adipose tissue, and the other components of metabolic syndrome.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
