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IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2024-09-14 DOI:10.1016/j.jpsychores.2024.111935

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引用次数: 0

摘要

目的研究青春期后期的抗压能力与日后罹患严重 COVID-19 和其他下呼吸道感染风险之间的关系。方法我们对 140 万瑞典男性进行了一项基于登记的队列研究，这些男性在 1968 年至 2005 年期间应征入伍。所有人都接受了心理学家的抗压能力评估，得分在 1 到 9 分之间。研究结果为2020年3月至2021年9月期间因COVID-19导致的住院或死亡，以及应征入伍至2020年1月期间因细菌性或病毒性肺炎导致的住院。次要目的是研究低心肺功能（CRF）与压力恢复能力之间在呼吸道感染方面的潜在混杂因素。以抗压能力得分高者为参照，经 CRF 和其他混杂因素调整后，得分最低者因 COVID-19 死亡的危险比（95 % CI）为 1.49（1.01-2.18）。相应的调整后细菌性肺炎住院危险比为 2.28（2.03-2.57），病毒性肺炎为 1.92（1.33-2.79）。结论抗压能力差是导致严重 COVID-19 以及细菌性和病毒性呼吸道肺炎终点的前瞻性因素，与 CRF 无关。这些研究结果表明，青少年晚期的抗压能力会对日后的免疫系统产生影响。

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Poor stress resilience in adolescence predicts higher risk of severe COVID-19 and other respiratory infections: A prospective cohort study of 1.4 million Swedish men

Objectives

To investigate the associations between stress resilience in late adolescence and later risk of severe COVID-19 and other lower respiratory infections. A secondary aim was to examine potential confounding between low cardiorespiratory fitness (CRF) and stress resilience in relation to respiratory infection.

Methods

We conducted a registry-based cohort study of 1.4 million Swedish men, undergoing military conscription between 1968 and 2005. All were assessed by a psychologist for stress resilience, receiving a score between 1 and 9. The outcomes were hospitalization or death due to COVID-19 from March 2020 to September 2021 and hospitalization due to bacterial or viral pneumonia from conscription until January 2020. A secondary aim was to examine potential confounding between low cardiorespiratory fitness (CRF) and stress resilience in relation to respiratory infection.

Results

Poor stress resilience in late adolescence is associated with later risk of severe lower respiratory infections. Using a high resilience score as the reference, the hazard ratio (95 % CI) for death due to COVID-19 for the lowest scores was 1.49 (1.01–2.18) adjusted for CRF and other confounders. The corresponding adjusted hazard ratios for hospitalization due to bacterial pneumonia were 2.28 (2.03–2.57) and for viral pneumonia 1.92 (1.33–2.79). No significant interaction was seen between stress resilience and CRF in the analysis.

Conclusions

Poor stress resilience is a prospective factor for severe COVID-19 as well as for bacterial and viral respiratory pneumonia endpoints, independent of CRF. These findings imply an effect of late adolescent stress resilience on the immune system later in life.

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.