基于大型光纤轴的卓越成像性能光学相干断层扫描微型探头

IF 3.5 2区 工程技术 Q2 OPTICS
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引用次数: 0

摘要

临床诊断越来越依赖于通过光学相干断层成像(OCT)内窥镜获得可视化图像,这种内窥镜体积小、聚焦深度大、分辨率高,而且不会损伤脆弱的组织和器官。然而,目前聚焦深度(DOF)和横向分辨率的相互制约限制了光学内窥镜探头的综合成像性能和广泛应用。为了克服固有的焦深-分辨率权衡问题,一种具有扩展贝塞尔焦距的低成本超薄光纤内窥镜 OCT 探头被提出并得到了验证。大直径无芯光纤(∼250 μm)和光纤微球(∼600 μm)扩大了照明光束的腰径。微球上可观的光纤轴心为产生准贝塞尔光束提供了机会,在 534 μm 的 DOF 范围内,准不变聚焦光斑尺寸的半最大值全宽(FWHM)直径约为 1.67 μm。通过对多个样本的成像,验证了基于光纤轴的 OCT 探头的成像性能和在各种应用中的巨大潜力。这种低成本、微型化和超高成像性能的光纤轴心探头对生物医学、临床诊断和干预应用中的 OCT 成像非常有吸引力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exceptional imaging performance optic coherence tomography miniature probe based on sizable fiber axicon

Clinical diagnosis increasingly relies on obtaining visualization images through optical coherence tomography (OCT) endoscopes with small-volume, large focusing depth, and high-resolution performance without damaging fragile tissues and organs. However, the mutual constraints of the depth of focus (DOF) and the lateral resolution currently limit the comprehensive imaging performance and widespread application of optical endoscopic probes. To overcome the inherent DOF-resolution tradeoff, a low-cost, ultra-thin fiber-optic endoscopic OCT probe with extended Bessel-like focus has been proposed and demonstrated. The waist diameter of the illumination beam is expanded by a large-diameter no core fiber (∼250 μm) and a fiber microsphere (∼600 μm). The sizable fiber axicon ground on the microsphere provides an opportunity to generate quasi-Bessel beam with a full width at half maxima (FWHM) diameter of the quasi-invariant focused spot-size of about 1.67 μm over the DOF range of 534 μm. The imaging performance and the vast potential for diverse applications of the fiber axicon-based OCT probe were validated by imaging of multiple samples. The low-cost, miniaturization, and ultrahigh imaging performance fiber-optic axicon probe are very attractive for OCT imaging in biomedical, clinical diagnosis, and intervention applications.

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来源期刊
Optics and Lasers in Engineering
Optics and Lasers in Engineering 工程技术-光学
CiteScore
8.90
自引率
8.70%
发文量
384
审稿时长
42 days
期刊介绍: Optics and Lasers in Engineering aims at providing an international forum for the interchange of information on the development of optical techniques and laser technology in engineering. Emphasis is placed on contributions targeted at the practical use of methods and devices, the development and enhancement of solutions and new theoretical concepts for experimental methods. Optics and Lasers in Engineering reflects the main areas in which optical methods are being used and developed for an engineering environment. Manuscripts should offer clear evidence of novelty and significance. Papers focusing on parameter optimization or computational issues are not suitable. Similarly, papers focussed on an application rather than the optical method fall outside the journal''s scope. The scope of the journal is defined to include the following: -Optical Metrology- Optical Methods for 3D visualization and virtual engineering- Optical Techniques for Microsystems- Imaging, Microscopy and Adaptive Optics- Computational Imaging- Laser methods in manufacturing- Integrated optical and photonic sensors- Optics and Photonics in Life Science- Hyperspectral and spectroscopic methods- Infrared and Terahertz techniques
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