Felipe Gomes Naveca, Tatiana Amaral Pires de Almeida, Victor Souza, Valdinete Nascimento, Dejanane Silva, Fernanda Nascimento, Matilde Mejía, Yasmin Silva de Oliveira, Luisa Rocha, Natana Xavier, Janis Lopes, Rodrigo Maito, Cátia Meneses, Tatyana Amorim, Luciana Fé, Fernanda Sindeaux Camelo, Samyly Coutinho de Aguiar Silva, Alexsandro Xavier de Melo, Leíse Gomes Fernandes, Marco Aurélio Almeida de Oliveira, Ana Ruth Arcanjo, Guilherme Araújo, Walter André Júnior, Renata Lia Coragem de Carvalho, Rosiane Rodrigues, Stella Albuquerque, Cristiane Mattos, Ciciléia Silva, Aline Linhares, Taynã Rodrigues, Francy Mariscal, Márcia Andréa Morais, Mayra Marinho Presibella, Nelson Fernando Quallio Marques, Anne Paiva, Karina Ribeiro, Deusilene Vieira, Jackson Alves da Silva Queiroz, Ana Maísa Passos-Silva, Lígia Abdalla, João Hugo Santos, Regina Maria Pinto de Figueiredo, Ana Cecília Ribeiro Cruz, Livia Neves Casseb, Jannifer Oliveira Chiang, Livia Vinhal Frutuoso, Agata Rossi, Lucas Freitas, Túlio de Lima Campos, Gabriel Luz Wallau, Emerson Moreira, Roberto Dias Lins Neto, Laura W. Alexander, Yining Sun, Ana Maria Bispo de Filippis, Tiago Gräf, Ighor Arantes, Ana I. Bento, Edson Delatorre, Gonzalo Bello
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Alexander, Yining Sun, Ana Maria Bispo de Filippis, Tiago Gräf, Ighor Arantes, Ana I. Bento, Edson Delatorre, Gonzalo Bello","doi":"10.1038/s41591-024-03300-3","DOIUrl":null,"url":null,"abstract":"<p>The Brazilian western Amazon is experiencing its largest laboratory-confirmed Oropouche virus (OROV) outbreak, with more than 6,300 reported cases between 2022 and 2024. Here, we sequenced and analyzed 382 OROV genomes from human samples collected in Amazonas, Acre, Rondônia, and Roraima states, between August 2022 and February 2024, to uncover the origin and genetic evolution of OROV in the current outbreak. Genomic analyses revealed that the upsurge of OROV cases in the Brazilian Amazon coincides with spread of a novel reassortant lineage containing the M segment of viruses detected in the eastern Amazon region (2009-2018) and the L and S segments of viruses detected in Peru, Colombia, and Ecuador (2008-2021). 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引用次数: 0
摘要
巴西亚马孙河流域西部正在爆发实验室确诊的最大规模的奥罗普切病毒（OROV）疫情，2022年至2024年期间报告的病例超过6300例。在此，我们对2022年8月至2024年2月期间在亚马孙州、阿克里州、朗多尼亚州和罗赖马州采集的382份人类样本中的OROV基因组进行了测序和分析，以揭示当前疫情中OROV的起源和基因演变。基因组分析表明，巴西亚马逊地区的 OROV 病例激增与新型变异株的传播不谋而合，该变异株包含在亚马逊东部地区检测到的病毒 M 段（2009-2018 年）以及在秘鲁、哥伦比亚和厄瓜多尔检测到的病毒 L 段和 S 段（2008-2021 年）。新型变异株可能于 2010 年至 2014 年间在亚马孙州出现，并在 2010 年代后半期通过远距离传播事件扩散。系统动力学重建表明，当前的 OROV 传播主要是由短程（2 千米）运动驱动的，这与病媒的飞行范围一致。然而，我们也检测到了相当大比例（22%）的长距离（10 公里）OROV 迁移，这与人类的病毒传播是一致的。我们的数据揭示了 OROV 在巴西亚马逊西部地区前所未有的传播和演变过程。
Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region
The Brazilian western Amazon is experiencing its largest laboratory-confirmed Oropouche virus (OROV) outbreak, with more than 6,300 reported cases between 2022 and 2024. Here, we sequenced and analyzed 382 OROV genomes from human samples collected in Amazonas, Acre, Rondônia, and Roraima states, between August 2022 and February 2024, to uncover the origin and genetic evolution of OROV in the current outbreak. Genomic analyses revealed that the upsurge of OROV cases in the Brazilian Amazon coincides with spread of a novel reassortant lineage containing the M segment of viruses detected in the eastern Amazon region (2009-2018) and the L and S segments of viruses detected in Peru, Colombia, and Ecuador (2008-2021). The novel reassortant likely emerged in the Amazonas state between 2010 and 2014 and spread through long-range dispersion events during the second half of the 2010s. Phylodynamics reconstructions showed that the current OROV spread was mainly driven by short-range (< 2 km) movements consistent with the flight range of vectors. Nevertheless, a substantial proportion (22%) of long-range (> 10 km) OROV migrations were also detected, consistent with viral dispersion by humans. Our data provides a view of the unprecedented spread and evolution of OROV in Brazilian western Amazon region.
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