Yannis Yan Liang, Mingqing Zhou, Yu He, Weijie Zhang, Qiqi Wu, Tong Luo, Jun Zhang, Fujun Jia, Lu Qi, Sizhi Ai, Jihui Zhang
{"title":"观察和遗传证据在孤独与多种疾病风险之间的关系上存在分歧","authors":"Yannis Yan Liang, Mingqing Zhou, Yu He, Weijie Zhang, Qiqi Wu, Tong Luo, Jun Zhang, Fujun Jia, Lu Qi, Sizhi Ai, Jihui Zhang","doi":"10.1038/s41562-024-01970-0","DOIUrl":null,"url":null,"abstract":"Loneliness—the subjective experience of social disconnection—is now widely regarded as a health risk factor. However, whether the associations between loneliness and multiple diseases are consistent with causal effects remains largely unexplored. Here we combined behavioural, genetic and hospitalization data from the UK Biobank to examine the associations of loneliness with a wide range of non-overlapping diseases. During a median 12.2-year follow-up, loneliness was associated with greater risks in 13 of 14 disease categories and 30 of 56 individual diseases considered. Of the 30 diseases significantly associated with loneliness, 26 had genetic data available for Mendelian randomization (MR) analyses. After Benjamini‒Hochberg correction and multiple sensitivity analyses within the MR framework, non-causal associations were identified between genetic liability to loneliness and 20 out of the 26 specific diseases, including cardiovascular diseases, type 2 diabetes mellitus, obesity, chronic liver diseases, chronic kidney disease, most neurological diseases and the other common diseases. Genetic liability to loneliness was only potentially causally associated with the remaining six diseases. Socioeconomic factors, health behaviours, baseline depressive symptoms and comorbidities largely explained the associations between loneliness and diseases. Overall, our study revealed a dissociation between observational and genetic evidence regarding the associations of loneliness with multiple diseases. These findings suggest that loneliness may serve as a potential surrogate marker rather than a causal risk factor for most diseases tested here. Loneliness was found to be linked to increased risk for 30 out of 56 diseases in a UK Biobank study. However, genetic analyses show that loneliness likely causes only six diseases. These findings suggest that loneliness is more a potential surrogate marker than a direct cause for most diseases.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"8 11","pages":"2209-2221"},"PeriodicalIF":21.4000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41562-024-01970-0.pdf","citationCount":"0","resultStr":"{\"title\":\"Observational and genetic evidence disagree on the association between loneliness and risk of multiple diseases\",\"authors\":\"Yannis Yan Liang, Mingqing Zhou, Yu He, Weijie Zhang, Qiqi Wu, Tong Luo, Jun Zhang, Fujun Jia, Lu Qi, Sizhi Ai, Jihui Zhang\",\"doi\":\"10.1038/s41562-024-01970-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Loneliness—the subjective experience of social disconnection—is now widely regarded as a health risk factor. However, whether the associations between loneliness and multiple diseases are consistent with causal effects remains largely unexplored. Here we combined behavioural, genetic and hospitalization data from the UK Biobank to examine the associations of loneliness with a wide range of non-overlapping diseases. During a median 12.2-year follow-up, loneliness was associated with greater risks in 13 of 14 disease categories and 30 of 56 individual diseases considered. Of the 30 diseases significantly associated with loneliness, 26 had genetic data available for Mendelian randomization (MR) analyses. After Benjamini‒Hochberg correction and multiple sensitivity analyses within the MR framework, non-causal associations were identified between genetic liability to loneliness and 20 out of the 26 specific diseases, including cardiovascular diseases, type 2 diabetes mellitus, obesity, chronic liver diseases, chronic kidney disease, most neurological diseases and the other common diseases. Genetic liability to loneliness was only potentially causally associated with the remaining six diseases. Socioeconomic factors, health behaviours, baseline depressive symptoms and comorbidities largely explained the associations between loneliness and diseases. Overall, our study revealed a dissociation between observational and genetic evidence regarding the associations of loneliness with multiple diseases. These findings suggest that loneliness may serve as a potential surrogate marker rather than a causal risk factor for most diseases tested here. Loneliness was found to be linked to increased risk for 30 out of 56 diseases in a UK Biobank study. However, genetic analyses show that loneliness likely causes only six diseases. 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Observational and genetic evidence disagree on the association between loneliness and risk of multiple diseases
Loneliness—the subjective experience of social disconnection—is now widely regarded as a health risk factor. However, whether the associations between loneliness and multiple diseases are consistent with causal effects remains largely unexplored. Here we combined behavioural, genetic and hospitalization data from the UK Biobank to examine the associations of loneliness with a wide range of non-overlapping diseases. During a median 12.2-year follow-up, loneliness was associated with greater risks in 13 of 14 disease categories and 30 of 56 individual diseases considered. Of the 30 diseases significantly associated with loneliness, 26 had genetic data available for Mendelian randomization (MR) analyses. After Benjamini‒Hochberg correction and multiple sensitivity analyses within the MR framework, non-causal associations were identified between genetic liability to loneliness and 20 out of the 26 specific diseases, including cardiovascular diseases, type 2 diabetes mellitus, obesity, chronic liver diseases, chronic kidney disease, most neurological diseases and the other common diseases. Genetic liability to loneliness was only potentially causally associated with the remaining six diseases. Socioeconomic factors, health behaviours, baseline depressive symptoms and comorbidities largely explained the associations between loneliness and diseases. Overall, our study revealed a dissociation between observational and genetic evidence regarding the associations of loneliness with multiple diseases. These findings suggest that loneliness may serve as a potential surrogate marker rather than a causal risk factor for most diseases tested here. Loneliness was found to be linked to increased risk for 30 out of 56 diseases in a UK Biobank study. However, genetic analyses show that loneliness likely causes only six diseases. These findings suggest that loneliness is more a potential surrogate marker than a direct cause for most diseases.
期刊介绍:
Nature Human Behaviour is a journal that focuses on publishing research of outstanding significance into any aspect of human behavior.The research can cover various areas such as psychological, biological, and social bases of human behavior.It also includes the study of origins, development, and disorders related to human behavior.The primary aim of the journal is to increase the visibility of research in the field and enhance its societal reach and impact.