肠道微生物群影响膀胱肿瘤的发展

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Urology Pub Date : 2024-09-16 DOI:10.1038/s41585-024-00947-y

Louise Lloyd

引用次数: 0

摘要

发表在《自然》（Nature）杂志上的最新研究表明，肠道微生物群的致癌物质代谢可能有助于化学物质诱导的膀胱癌发生。在小鼠模型中，长期暴露于N-丁基-N-（4-羟基丁基）-亚硝胺（BBN）会诱发膀胱癌。因此，研究人员利用这一模型来研究肠道微生物群对 BBN 诱导的癌变和毒物动力学的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gut microbiota influence bladder tumour development

New research, published in Nature, shows that gut microbiota carcinogen metabolism could contribute to chemical-induced carcinogenesis in the bladder.

Chronic exposure to N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) induces bladder cancer in mouse models. Thus, the investigators used this model to examine the influence of gut microbiota on BBN-induced carcinogenesis and toxicokinetics.

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来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.