Mirza Zaka Pratama, Cesarius Singgih Wahono, Ahmad Bayhaqi Nasir Aslam, Syahrul Chilmi, Vidia Purnama Sari, Anugrah Abdurrohman, Ike Sulistiyowati, Aldo Aditya, Maxie Felix Johono, Robert
{"title":"T 细胞衰老与系统性红斑狼疮患者的早期动脉粥样硬化有关","authors":"Mirza Zaka Pratama, Cesarius Singgih Wahono, Ahmad Bayhaqi Nasir Aslam, Syahrul Chilmi, Vidia Purnama Sari, Anugrah Abdurrohman, Ike Sulistiyowati, Aldo Aditya, Maxie Felix Johono, Robert","doi":"10.1111/1756-185X.15339","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>To investigate the correlation between T-cell senescence with the atherosclerosis markers in patients with systemic lupus erythematosus (SLE).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The study participants were 40 female SLE patients aged 18–45 years who met the 2019 EULAR/ACR criteria and 40 healthy individuals. The atherosclerosis markers were investigated using the Doppler ultrasonography examinations to measure the cIMT (carotid intima-media thickness) and flow-mediated dilation (FMD) and serological markers using soluble ICAM-1 and VCAM-1. Flow cytometry of CD4<sup>+</sup>CD57<sup>+</sup>, CD8<sup>+</sup>CD57<sup>+</sup>, CD4<sup>+</sup>CD28<sup>null</sup>, and CD8<sup>+</sup>CD28<sup>null</sup> T cells were used to assess the immunosenescence markers.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The cIMT (<i>p</i> < .001), sICAM-1 (<i>p</i> < .001), and sVCAM-1 (<i>p</i> < .001) were significantly higher in SLE patients compared with control, while FMD was significantly lower in SLE patients (<i>p</i> < .001). The percentages of all T-cell senescence markers are also significantly higher in SLE patients than in healthy individuals. Positive correlations were shown between cIMT with the CD4<sup>+</sup>CD57<sup>+</sup> (<i>R</i> = .301, <i>p</i> = .005), CD4<sup>+</sup>CD28<sup>null</sup> (<i>R</i> = .448, <i>p</i> < .001), and CD8<sup>+</sup>CD28<sup>null</sup> (<i>R</i> = .422, <i>p</i> < .001). Conversely, negative correlations were demonstrated between the FMD with CD4<sup>+</sup>CD57<sup>+</sup> (<i>R</i> = −.236, <i>p</i> = .023), CD8<sup>+</sup>CD57<sup>+</sup> (<i>R</i> = −.409, <i>p</i> < .001), CD4<sup>+</sup>CD28<sup>null</sup> (<i>R</i> = −.422, <i>p</i> < .001), and CD8<sup>+</sup>CD28<sup>null</sup> (<i>R</i> = −.318, <i>p</i> = .003). The soluble markers of sICAM-1 and sVCAM-1 were also positively correlated with the T-cell senescence markers.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Early sign of atherosclerosis was demonstrated in patients with SLE in this study. T-cell senescence markers had significant correlations with the atherosclerosis markers, including the cIMT, FMD, and soluble adhesion molecules levels. Understanding the link between immunosenescence and atherosclerosis might help to identify a new method for early detection and treatment of atherosclerosis in SLE.</p>\n </section>\n </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 9","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"T-cell senescence was correlated with early atherosclerosis in patients with systemic lupus erythematosus\",\"authors\":\"Mirza Zaka Pratama, Cesarius Singgih Wahono, Ahmad Bayhaqi Nasir Aslam, Syahrul Chilmi, Vidia Purnama Sari, Anugrah Abdurrohman, Ike Sulistiyowati, Aldo Aditya, Maxie Felix Johono, Robert\",\"doi\":\"10.1111/1756-185X.15339\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>To investigate the correlation between T-cell senescence with the atherosclerosis markers in patients with systemic lupus erythematosus (SLE).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>The study participants were 40 female SLE patients aged 18–45 years who met the 2019 EULAR/ACR criteria and 40 healthy individuals. The atherosclerosis markers were investigated using the Doppler ultrasonography examinations to measure the cIMT (carotid intima-media thickness) and flow-mediated dilation (FMD) and serological markers using soluble ICAM-1 and VCAM-1. Flow cytometry of CD4<sup>+</sup>CD57<sup>+</sup>, CD8<sup>+</sup>CD57<sup>+</sup>, CD4<sup>+</sup>CD28<sup>null</sup>, and CD8<sup>+</sup>CD28<sup>null</sup> T cells were used to assess the immunosenescence markers.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The cIMT (<i>p</i> < .001), sICAM-1 (<i>p</i> < .001), and sVCAM-1 (<i>p</i> < .001) were significantly higher in SLE patients compared with control, while FMD was significantly lower in SLE patients (<i>p</i> < .001). The percentages of all T-cell senescence markers are also significantly higher in SLE patients than in healthy individuals. Positive correlations were shown between cIMT with the CD4<sup>+</sup>CD57<sup>+</sup> (<i>R</i> = .301, <i>p</i> = .005), CD4<sup>+</sup>CD28<sup>null</sup> (<i>R</i> = .448, <i>p</i> < .001), and CD8<sup>+</sup>CD28<sup>null</sup> (<i>R</i> = .422, <i>p</i> < .001). Conversely, negative correlations were demonstrated between the FMD with CD4<sup>+</sup>CD57<sup>+</sup> (<i>R</i> = −.236, <i>p</i> = .023), CD8<sup>+</sup>CD57<sup>+</sup> (<i>R</i> = −.409, <i>p</i> < .001), CD4<sup>+</sup>CD28<sup>null</sup> (<i>R</i> = −.422, <i>p</i> < .001), and CD8<sup>+</sup>CD28<sup>null</sup> (<i>R</i> = −.318, <i>p</i> = .003). The soluble markers of sICAM-1 and sVCAM-1 were also positively correlated with the T-cell senescence markers.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Early sign of atherosclerosis was demonstrated in patients with SLE in this study. T-cell senescence markers had significant correlations with the atherosclerosis markers, including the cIMT, FMD, and soluble adhesion molecules levels. Understanding the link between immunosenescence and atherosclerosis might help to identify a new method for early detection and treatment of atherosclerosis in SLE.</p>\\n </section>\\n </div>\",\"PeriodicalId\":14330,\"journal\":{\"name\":\"International Journal of Rheumatic Diseases\",\"volume\":\"27 9\",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Rheumatic Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/1756-185X.15339\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Rheumatic Diseases","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/1756-185X.15339","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
T-cell senescence was correlated with early atherosclerosis in patients with systemic lupus erythematosus
Aim
To investigate the correlation between T-cell senescence with the atherosclerosis markers in patients with systemic lupus erythematosus (SLE).
Methods
The study participants were 40 female SLE patients aged 18–45 years who met the 2019 EULAR/ACR criteria and 40 healthy individuals. The atherosclerosis markers were investigated using the Doppler ultrasonography examinations to measure the cIMT (carotid intima-media thickness) and flow-mediated dilation (FMD) and serological markers using soluble ICAM-1 and VCAM-1. Flow cytometry of CD4+CD57+, CD8+CD57+, CD4+CD28null, and CD8+CD28null T cells were used to assess the immunosenescence markers.
Results
The cIMT (p < .001), sICAM-1 (p < .001), and sVCAM-1 (p < .001) were significantly higher in SLE patients compared with control, while FMD was significantly lower in SLE patients (p < .001). The percentages of all T-cell senescence markers are also significantly higher in SLE patients than in healthy individuals. Positive correlations were shown between cIMT with the CD4+CD57+ (R = .301, p = .005), CD4+CD28null (R = .448, p < .001), and CD8+CD28null (R = .422, p < .001). Conversely, negative correlations were demonstrated between the FMD with CD4+CD57+ (R = −.236, p = .023), CD8+CD57+ (R = −.409, p < .001), CD4+CD28null (R = −.422, p < .001), and CD8+CD28null (R = −.318, p = .003). The soluble markers of sICAM-1 and sVCAM-1 were also positively correlated with the T-cell senescence markers.
Conclusion
Early sign of atherosclerosis was demonstrated in patients with SLE in this study. T-cell senescence markers had significant correlations with the atherosclerosis markers, including the cIMT, FMD, and soluble adhesion molecules levels. Understanding the link between immunosenescence and atherosclerosis might help to identify a new method for early detection and treatment of atherosclerosis in SLE.
期刊介绍:
The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.