与机制和行为相关的颞下颌关节差异

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-09-14 DOI:10.1177/00220345241265670

J.C. Nickel, Y.M. Gonzalez, Y. Liu, H. Liu, L.M. Gallo, L.R. Iwasaki

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引用次数: 0

摘要

颞下颌关节（TMJ）组织的疲劳反映了加载幅度（能量密度；ED）和频率（下颌肌肉负荷因子；DF）的影响。这项观察性研究测量了这些变量，并测试了有颞下颌关节盘移位（±D）和无颞下颌关节盘移位受试者的机械行为评分（MBS = ED2 × DF）和组成变量的差异。根据机构审查委员会和 STROBE 指南，我们获得了书面知情同意，并通过检查和成像协议确定了符合条件的成年受试者。具体来说，磁共振成像用于将受试者的颞下颌关节分配到±D组。受试者接受了记录现场下颌肌肉活动的训练，并从中确定了 DF（记录时间的百分比）。使用颞下颌关节负荷模型和活体动态立体测量法估算 EDs（mJ/mm3）。多变量方差分析、事后独立 t 检验和 K-means 聚类分析确定了显著的组间差异（P < 0.05）。在筛选出的 242 人中，有 65 名女性（颞下颌关节：78 +D，52 -D）和 53 名男性（颞下颌关节：39 +D，67 -D）参加。受试者进行了 312 次日间记录和 319 次夜间记录，平均持续时间分别为 6.0 ± 0.2 小时和 7.6 ± 0.1 小时，以及 219 次（右侧 114 次，左侧 105 次）完整的动态立体测量记录。+D颞下颌关节的平均ED是-D颞下颌关节的2倍，且明显大于-D颞下颌关节（P < 0.0001）。日间与夜间相比，颌间肌和颞肌的 DFs 平均大 3 倍，日间与夜间相比，颌间肌和颞肌的 DFs 分别大 1.8 倍和 3.0 倍。女性+D颞下颌关节的日间咀嚼肌MBS值最大，为621 ± 212 (mJ/mm3)2%，与-D颞下颌关节相比，男女咀嚼肌MBS值在白天和夜间分别大2-43倍。聚类分析（P < 0.0001）确定了第 2 组和第 3 组，其中 87% 为 +D TMJ，其平均 MBS 比第 1 组大 21 倍。结果表明，MBS 是预测颞下颌关节结构退行性变化的平衡、进展或逆转的潜在生物标志物。

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Mechanics- and Behavior-Related Temporomandibular Joint Differences

Fatigue of temporomandibular joint (TMJ) tissues reflects the effects of magnitude (energy density; ED) and frequency of loading (jaw muscle duty factor; DF). This observational study measured these variables and tested for differences in mechanobehavior scores (MBS = ED2 × DF) and component variables in subjects with and without TMJ disc displacement (±D). In accordance with Institutional Review Board and STROBE guidelines, written informed consent was obtained, and examination and imaging protocols identified eligible adult subjects. Specifically, magnetic resonance imaging was used to assign subjects’ TMJs to ±D groups. Subjects were trained to record in-field jaw muscle activities, from which DFs (percentage of recording time) were determined. EDs (mJ/mm3) were estimated using modeled TMJ loads and in vivo dynamic stereometry. Multivariate analysis of variance, post hoc independent t tests, and K-means cluster analysis identified significant group differences ( P < 0.05). Of 242 individuals screened, 65 females (TMJs: 78 +D, 52 −D) and 53 males (TMJs: 39 +D, 67 −D) participated. Subjects produced 312 daytime and 319 nighttime recordings of average duration 6.0 ± 0.2 h and 7.6 ± 0.1 h, respectively, and 219 (114 right, 105 left) intact dynamic stereometry recordings. Average EDs were 2-fold and significantly larger in +D than −D TMJs ( P < 0.0001). DFs were on average 3-fold larger during the daytime versus nighttime for both masseter and temporalis muscles and 1.8- and 3.0-fold larger for the masseter versus temporalis muscle during the daytime and nighttime, respectively. Daytime masseter MBSs for +D TMJs in females were the largest overall at 621 ± 212 (mJ/mm3)2% and 2- to 43-fold larger versus −D TMJs in both sexes during daytime and nighttime. Cluster analysis ( P < 0.0001) identified groups 2 and 3, which comprised 87% +D TMJs and had average MBSs 21-fold larger than group 1. The results show MBS as a potential biomarker to predict homeostasis versus progression or reversal of degenerative TMJ structural changes.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.