以线粒体为靶点的小分子药物是一种创新的癌症治疗方法

IF 4.4 2区 生物学 Q2 CELL BIOLOGY
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引用次数: 0

摘要

细胞死亡逃避是人类恶性肿瘤的一个显著特征,也是导致治疗无效的一个重要因素。由于致癌物质对细胞死亡机制的抑制,现有的治疗方案似乎无法奏效。线粒体是细胞的动力室,但同时也是自我毁灭武器的储存库。在癌细胞中,线粒体结构和活动的变化一直被记录在案。近年来,人们越来越关注利用线粒体作为治疗癌症的靶向方法。人们将相当多的注意力集中在开发递送系统上,这些系统有选择性地向线粒体递送被称为 "丝裂霉素 "的小分子,最终目的是调节癌细胞的生理机能。这篇综述总结了小分子靶向线粒体治疗癌症的原理和机制,以及它们对线粒体的影响。本文简明扼要地概述了在癌症治疗中以线粒体为靶点进行治疗的原理和机制,尤其侧重于使用小分子靶向治疗。这篇综述还研究了每一类中作为潜在癌症治疗药物的各种小分子类型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Small molecules targeting mitochondria as an innovative approach to cancer therapy

Cellular death evasion is a defining characteristic of human malignancies and a significant contributor to therapeutic inefficacy. As a result of oncogenic inhibition of cell death mechanisms, established therapeutic regimens seems to be ineffective. Mitochondria serve as the cellular powerhouses, but they also function as repositories of self-destructive weaponry. Changes in the structure and activities of mitochondria have been consistently documented in cancer cells. In recent years, there has been an increasing focus on using mitochondria as a targeted approach for treating cancer. Considerable attention has been devoted to the development of delivery systems that selectively aim to deliver small molecules called “mitocans” to mitochondria, with the ultimate goal of modulating the physiology of cancer cells. This review summarizes the rationale and mechanism of mitochondrial targeting with small molecules in the treatment of cancer, and their impact on the mitochondria. This paper provides a concise overview of the reasoning and mechanism behind directing treatment towards mitochondria in cancer therapy, with a particular focus on targeting using small molecules. This review also examines diverse small molecule types within each category as potential therapeutic agents for cancer.

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来源期刊
Cellular signalling
Cellular signalling 生物-细胞生物学
CiteScore
8.40
自引率
0.00%
发文量
250
审稿时长
27 days
期刊介绍: Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.
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