沃尔夫拉姆综合征中的内质网-线粒体锁定现象

IF 4.3 2区生物学 Q2 CELL BIOLOGY

Cell calcium Pub Date : 2024-09-12 DOI:10.1016/j.ceca.2024.102955

Riccardo Filadi , Paola Pizzo

引用次数: 0

摘要

沃尔夫拉姆综合征（WS）是一种无法治愈的常染色体隐性遗传疾病，最初被描述为线粒体病。在最近的一项研究中，Liiv 及其同事发现，在 WS 模型中，内质网（ER）到线粒体的钙穿梭障碍是线粒体功能障碍的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Endoplasmic reticulum-mitochondria lockdown in Wolfram syndrome

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Endoplasmic reticulum-mitochondria lockdown in Wolfram syndrome

Wolfram syndrome (WS) is an incurable autosomal recessive disorder originally described as a mitochondriopathy. In a recent work, Liiv and colleagues found that an impaired endoplasmic reticulum (ER)-to-mitochondria calcium shuttling underlies mitochondrial dysfunction in WS models.

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来源期刊

Cell calcium 生物-细胞生物学

CiteScore

8.70

自引率

5.00%

发文量

115

审稿时长

35 days

期刊介绍： Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes