蝾螈肢体再生过程中的假定上皮-间充质转化：当前视角与未来研究

IF 4.1 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Annals of the New York Academy of Sciences Pub Date : 2024-09-13 DOI:10.1111/nyas.15210

Ryan T. Kim, Jessica L. Whited

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引用次数: 0

摘要

以前的研究表明，上皮-间质转化（EMT）与蝾螈的肢体再生有关。在这篇综述中，我们描述了EMT在斧头鱼和其他蝾螈肢体再生的每个阶段中可能发挥的作用。我们推测，EMT 和类 EMT 基因表达程序可能调控肢体再生过程中的三个主要细胞过程：（1）伤口闭合过程中角质细胞的迁移；（2）发生 EMT 的上皮细胞对残肢的短暂入侵；以及（3）非上皮胚芽祖细胞利用类 EMT 程序摆脱其龛位的限制。最后，我们提出了EMT在肢体再生过程中值得进一步研究的非传统作用，包括替代性EMT调节因子、干细胞活化以及异常EMT诱导的纤维化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Putative epithelial–mesenchymal transitions during salamander limb regeneration: Current perspectives and future investigations

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Putative epithelial–mesenchymal transitions during salamander limb regeneration: Current perspectives and future investigations

Previous studies have implicated epithelial–mesenchymal transition (EMT) in salamander limb regeneration. In this review, we describe putative roles for EMT during each stage of limb regeneration in axolotls and other salamanders. We hypothesize that EMT and EMT-like gene expression programs may regulate three main cellular processes during limb regeneration: (1) keratinocyte migration during wound closure; (2) transient invasion of the stump by epithelial cells undergoing EMT; and (3) use of EMT-like programs by non-epithelial blastemal progenitor cells to escape the confines of their niches. Finally, we propose nontraditional roles for EMT during limb regeneration that warrant further investigation, including alternative EMT regulators, stem cell activation, and fibrosis induced by aberrant EMT.

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来源期刊

Annals of the New York Academy of Sciences 综合性期刊-综合性期刊

CiteScore

11.00

自引率

1.90%

发文量

193

审稿时长

2-4 weeks

期刊介绍： Published on behalf of the New York Academy of Sciences, Annals of the New York Academy of Sciences provides multidisciplinary perspectives on research of current scientific interest with far-reaching implications for the wider scientific community and society at large. Each special issue assembles the best thinking of key contributors to a field of investigation at a time when emerging developments offer the promise of new insight. Individually themed, Annals special issues stimulate new ways to think about science by providing a neutral forum for discourse—within and across many institutions and fields.