表面增强拉曼散射 (SERS) 光谱在核酸检测中的应用

IF 6.5 2区 物理与天体物理 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Aleksandra Michałowska, Andrzej Kudelski
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引用次数: 0

摘要

核酸(脱氧核糖核酸(DNA)和核糖核酸(RNA))是所有生物体的重要组成部分,DNA 负责编码遗传信息,RNA 负责促进重要的生物过程。检测具有特定序列的核酸对于识别生物体和诊断遗传疾病至关重要。由于表面增强拉曼光谱(SERS)被认为是最有前途的分析方法之一,与其他技术相比,它具有分析时间短、灵敏度高等重要优点,因此许多研究小组都在尝试将 SERS 应用于核酸检测。本综述将讨论如何将 SERS 光谱用于 DNA/RNA 检测。从 SERS 理论概述开始,我们深入探讨了各种 SERS DNA/RNA 传感器,包括基于核酸 SERS 光谱直接分析的传感器,以及基于探针和目标核酸选择性杂交的多种类型的传感器。我们将介绍各种灵敏度和可靠性更高的传感器是如何发展起来的(从文献中描述的第一种 SERS DNA/RNA 传感器到最近开发的传感器)。我们还讨论了用于核酸检测和测定的 SERS 传感器开发所面临的挑战和未来发展方向。本综述旨在帮助研究人员了解该领域的细微差别,并促进 SERS 光谱在医疗领域的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Applications of surface enhanced Raman scattering (SERS) spectroscopy for detection of nucleic acids
Nucleic acids (deoxyribonucleic acid – DNA and ribonucleic acid – RNA) are essential components of all living organisms, with DNA encoding genetic information and RNA facilitating vital biological processes. The detection of nucleic acids having a specific sequence is crucial for identifying organisms and diagnosing genetic diseases. Because surface-enhanced Raman spectroscopy (SERS) is considered as one of the most promising analytical methods that offers important benefits such as short analysis time and exceptional sensitivity compared to other techniques, many groups are trying to apply SERS for nucleic acid detection. This review discusses how SERS spectroscopy can be used for DNA/RNA detection. Beginning with an overview of SERS theory, we delve into various SERS DNA/RNA sensors, including those based on a direct analysis of the SERS spectra of nucleic acids, and many types of sensors based on a selective hybridisation of probe and target nucleic acids. We describe how various types of sensors with increased sensitivity and reliability have evolved (from the first SERS DNA/RNA sensors described in the literature to recently developed ones). Challenges and future directions in SERS sensor development for nucleic acid detection and determination are also discussed. This comprehensive review aims to help researchers understand the field’s nuances, and to foster advancements in the use of SERS spectroscopy in the medical sector.
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来源期刊
Nanophotonics
Nanophotonics NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
13.50
自引率
6.70%
发文量
358
审稿时长
7 weeks
期刊介绍: Nanophotonics, published in collaboration with Sciencewise, is a prestigious journal that showcases recent international research results, notable advancements in the field, and innovative applications. It is regarded as one of the leading publications in the realm of nanophotonics and encompasses a range of article types including research articles, selectively invited reviews, letters, and perspectives. The journal specifically delves into the study of photon interaction with nano-structures, such as carbon nano-tubes, nano metal particles, nano crystals, semiconductor nano dots, photonic crystals, tissue, and DNA. It offers comprehensive coverage of the most up-to-date discoveries, making it an essential resource for physicists, engineers, and material scientists.
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