肽基抗菌剂的进展:应对新出现的耐药性感染的可能选择

IF 15.9 1区 化学 Q1 CHEMISTRY, PHYSICAL
Nitin Yadav , Virander S. Chauhan
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引用次数: 0

摘要

近年来,耐多药病原微生物(MDROs)对传统抗生素表现出强大的抗药性,已成为人类健康的严重威胁。这给现代医学带来了严峻的挑战,因为我们只能通过有限的选择来对付这些生命力顽强的细菌。尽管科学家们为开发针对这些病原体的新型抗生素做出了巨大努力,但寻找新型抗菌分子的工作却变得越来越艰巨。幸运的是,大自然以阳离子抗菌肽(AMPs)及其合成对应物的形式提供了一种潜在的解决方案。AMPs 是天然存在的肽类物质,通过破坏细菌细胞膜,阻碍其生存和繁殖,在抗击细菌感染方面显示出良好的功效。这些肽及其合成模拟物为抗击抗生素耐药性提供了令人兴奋的选择。它们有可能成为对抗 MDROs 的有力工具,为改进保护社区的战略带来希望。大量研究已经探索了 AMPs 的多样性、历史和结构-性能关系,研究了它们的两亲性以破坏膜和作用机制。然而,尽管 AMPs 具有治疗前景,但也面临着一些有据可查的局限性。在这些挑战中,最突出的是药物动力学特性差,阻碍了在体内达到治疗水平。此外,一些 AMPs 表现出毒性和易被蛋白酶裂解的特性,导致其半衰期较短,在动物模型中的疗效降低。这些局限性对开发基于 AMP 的有效治疗方法构成了障碍。此外,与 AMP 相关的高昂制造成本也会严重阻碍其广泛应用。在这篇综述中,我们旨在介绍有关不同 AMP 的实验和理论见解,尤其侧重于抗菌肽 (ABP)。我们的目标是通过大量文献和同行评审研究,简明扼要地概述基于肽的候选药物。我们还探讨了 AMP 开发的最新进展,并讨论了研究人员在将这些分子推向临床试验时所面临的挑战。我们的主要目标是全面概述当前的 AMP 和 ABP 研究,为开发更精确、更有效的细菌感染疗法提供指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Advancements in peptide-based antimicrobials: A possible option for emerging drug-resistant infections

Advancements in peptide-based antimicrobials: A possible option for emerging drug-resistant infections

In recent years, multidrug-resistant pathogenic microorganisms (MDROs) have emerged as a severe threat to human health, exhibiting robust resistance to traditional antibiotics. This has created a formidable challenge in modern medicine as we grapple with limited options to combat these resilient bacteria. Despite extensive efforts by scientists to develop new antibiotics targeting these pathogens, the quest for novel antibacterial molecules has become increasingly arduous. Fortunately, nature offers a potential solution in the form of cationic antimicrobial peptides (AMPs) and their synthetic counterparts. AMPs, naturally occurring peptides, have displayed promising efficacy in fighting bacterial infections by disrupting bacterial cell membranes, hindering their survival and reproduction. These peptides, along with their synthetic mimics, present an exciting alternative in combating antibiotic resistance. They hold the potential to emerge as a formidable tool against MDROs, offering hope for improved strategies to protect communities. Extensive research has explored the diversity, history, and structure-properties relationship of AMPs, investigating their amphiphilic nature for membrane disruption and mechanisms of action. However, despite their therapeutic promise, AMPs face several documented limitations. Among these challenges, poor pharmacokinetic properties stand out, impeding the attainment of therapeutic levels in the body. Additionally, some AMPs exhibit toxicity and susceptibility to protease cleavage, leading to a short half-life and reduced efficacy in animal models. These limitations pose obstacles in developing effective treatments based on AMPs. Furthermore, the high manufacturing costs associated with AMPs could significantly hinder their widespread use. In this review, we aim to present experimental and theoretical insights into different AMPs, focusing specifically on antibacterial peptides (ABPs). Our goal is to offer a concise overview of peptide-based drug candidates, drawing from a wide array of literature and peer-reviewed studies. We also explore recent advancements in AMP development and discuss the challenges researchers face in moving these molecules towards clinical trials. Our main objective is to offer a comprehensive overview of current AMP and ABP research to guide the development of more precise and effective therapies for bacterial infections.

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来源期刊
CiteScore
28.50
自引率
2.60%
发文量
175
审稿时长
31 days
期刊介绍: "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.
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