合成编程组织工程中的天然细胞-细胞通讯途径

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
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引用次数: 0

摘要

组织模式化是将不同细胞类型定位到正确位置的过程,对组织功能至关重要,因此也是组织工程学的核心目标。发育中的胚胎采用多种基于细胞相互作用的机制来稳健地进行组织模式化,例如指定中枢神经系统的不同区域和排列内耳中的所有毛细胞。这些事件的长度范围很广,而且都必须以细胞级的精度来指定,这给使用传统工程方法在体外再造这种模式带来了挑战。合成发育生物学作为一个新兴领域,通过利用天然组织使用的分子机制来编程细胞的自组织行为,为组织模式化提供了一种补充方法。在此,我们回顾了在利用这些模块对培养细胞进行编程方面取得的进展。这些模块可用于生物医学组织工程,作为现有体外生成形态复杂的多细胞型组织方法的补充。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthetically programming natural cell–cell communication pathways for tissue engineering

Tissue patterning, the process of localizing different cell types to the right place, is critical for tissue function and thus a central goal for tissue engineering. Developing embryos employ diverse cell interaction-based mechanisms to robustly pattern tissues, such as specifying different regions of the central nervous system and aligning all the hair cells in the inner ear. These events range in lengthscale and must all be specified with cell-level precision, imposing challenges for recreating such patterns in vitro using conventional engineering approaches. Synthetic developmental biology as an emerging field provides a complementary approach for patterning tissues, by harnessing the molecular mechanisms used by natural tissues to program self-organizing behavior of the cells. Here we review advances in adapting these modules to program cells in culture. These modules could potentially be used for biomedical tissue engineering, as a complement to existing methods for generating morphologically complex multi-cell-type tissues in vitro.

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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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