碳 11 标记甲氧苄啶的合成、放射性标记和临床前生物分布

IF 1.5 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-09-13 DOI:10.1007/s10967-024-09758-2

Pardeep Kumar, Aishwarya Kumar, Deeksha Muralidhar, Pralay mallik, Pratap Chandra Acharya

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引用次数: 0

摘要

在这项研究中，我们用碳-11 [11C]标记了甲氨醋酚作为 PET 成像放射性示踪剂。利用[11C]甲基碘使对乙酰氨基酚与[11C]甲基碘在碱存在下发生反应，从而进行放射性标记。[11C]甲基碘在 70 °C、5 分钟的甲基化反应中合成了[11C]甲基乙酰胺，其放射化学纯度为 99.3 ± 0.4 %，放射化学收率为 34.6 ± 4.7 %。组织分布显示，5 分钟后，血池中的摄取量较高，随后肺、肝和脾的摄取量增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis, radiolabeling and preclinical biodistribution of carbon-11 labeled methacetin

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Synthesis, radiolabeling and preclinical biodistribution of carbon-11 labeled methacetin

In this study, we have labeled methacetin with carbon-11 [¹¹C] as a PET imaging radiotracer. The radiolabeling was carried out by reacting acetaminophen with [¹¹C]methyl iodide in the presence of a base using [¹¹C]methyl iodide. [¹¹C]methacetin was synthesized via methylation at 70 °C for 5 min with a radiochemical purity of 99.3 ± 0.4 % and radiochemical yield was 34.6 ± 4.7 %. The tissue distribution showed higher uptake in blood pool at 5 min followed by increased uptake in lungs, liver and spleen.

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.