Almas Ishaque, Avadhesh Kumar, Mehtab Parveen, Nursabah Sarikavakli, Shahab A. A. Nami
{"title":"新型原位 Ca2+ 功能化三元 GO/PVP/CMC 纳米复合水凝胶的持续氨苄西林负载和释放能力","authors":"Almas Ishaque, Avadhesh Kumar, Mehtab Parveen, Nursabah Sarikavakli, Shahab A. A. Nami","doi":"10.1007/s10924-024-03371-w","DOIUrl":null,"url":null,"abstract":"<div><p>A novel pH sensitive antibiotic carrier hydrogel was synthesized having sustained drug releasing capabilities. The in-situ polymerization of Graphene oxide (GO), Polyvinyl pyrrolidone (PVP), and Carboxymethyl cellulose (CMC) of varying stoichiometry having Ca<sup>2+</sup> as a linker yielded ternary nanocomposite hydrogels GO/PVP/CMC-II and GO/PVP/CMC-III. The physicochemical, structural, morphological and swelling properties of the binary nanocomposite GO/PVP and ternary nanocomposite hydrogels, GO/PVP/CMC were investigated using FTIR, XRD, SEM, TEM, TGA and DTA. FTIR and XRD confirm successive formation of ternary hydrogels. The hydrogels swelling studies at various pH levels viz. 4.5, 7 and 9.2, show that the swelling ability can be proportionally correlated with CMC concentration. To ensure the efficacy of this innovative hydrogel drug release application, an in vitro Ampicillin loading and release efficiency experiment at pH 7.2 (close to blood pH 7.3–7.5) was performed. Ternary hydrogels GO/PVP/CMC-II and GO/PVP/CMC-III exhibited sustained drug loading and release kinetics (72 h).</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"32 12","pages":"6425 - 6439"},"PeriodicalIF":4.7000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sustained Ampicillin Loading and Releasing Ability of Novel In-Situ Ca2+ Functionalized Ternary GO/PVP/CMC Nanocomposite Hydrogel\",\"authors\":\"Almas Ishaque, Avadhesh Kumar, Mehtab Parveen, Nursabah Sarikavakli, Shahab A. A. Nami\",\"doi\":\"10.1007/s10924-024-03371-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A novel pH sensitive antibiotic carrier hydrogel was synthesized having sustained drug releasing capabilities. The in-situ polymerization of Graphene oxide (GO), Polyvinyl pyrrolidone (PVP), and Carboxymethyl cellulose (CMC) of varying stoichiometry having Ca<sup>2+</sup> as a linker yielded ternary nanocomposite hydrogels GO/PVP/CMC-II and GO/PVP/CMC-III. The physicochemical, structural, morphological and swelling properties of the binary nanocomposite GO/PVP and ternary nanocomposite hydrogels, GO/PVP/CMC were investigated using FTIR, XRD, SEM, TEM, TGA and DTA. FTIR and XRD confirm successive formation of ternary hydrogels. The hydrogels swelling studies at various pH levels viz. 4.5, 7 and 9.2, show that the swelling ability can be proportionally correlated with CMC concentration. To ensure the efficacy of this innovative hydrogel drug release application, an in vitro Ampicillin loading and release efficiency experiment at pH 7.2 (close to blood pH 7.3–7.5) was performed. Ternary hydrogels GO/PVP/CMC-II and GO/PVP/CMC-III exhibited sustained drug loading and release kinetics (72 h).</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":659,\"journal\":{\"name\":\"Journal of Polymers and the Environment\",\"volume\":\"32 12\",\"pages\":\"6425 - 6439\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Polymers and the Environment\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10924-024-03371-w\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, ENVIRONMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Polymers and the Environment","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s10924-024-03371-w","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}
Sustained Ampicillin Loading and Releasing Ability of Novel In-Situ Ca2+ Functionalized Ternary GO/PVP/CMC Nanocomposite Hydrogel
A novel pH sensitive antibiotic carrier hydrogel was synthesized having sustained drug releasing capabilities. The in-situ polymerization of Graphene oxide (GO), Polyvinyl pyrrolidone (PVP), and Carboxymethyl cellulose (CMC) of varying stoichiometry having Ca2+ as a linker yielded ternary nanocomposite hydrogels GO/PVP/CMC-II and GO/PVP/CMC-III. The physicochemical, structural, morphological and swelling properties of the binary nanocomposite GO/PVP and ternary nanocomposite hydrogels, GO/PVP/CMC were investigated using FTIR, XRD, SEM, TEM, TGA and DTA. FTIR and XRD confirm successive formation of ternary hydrogels. The hydrogels swelling studies at various pH levels viz. 4.5, 7 and 9.2, show that the swelling ability can be proportionally correlated with CMC concentration. To ensure the efficacy of this innovative hydrogel drug release application, an in vitro Ampicillin loading and release efficiency experiment at pH 7.2 (close to blood pH 7.3–7.5) was performed. Ternary hydrogels GO/PVP/CMC-II and GO/PVP/CMC-III exhibited sustained drug loading and release kinetics (72 h).
期刊介绍：
The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.
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