Jia Zhang, Tianjun Xing, Attalla F. El-kott, Ali G. Alkhathami, Abdullah A. Alamri
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Quince Seed Mucilage Mediated Biosynthesis of Gold Nanoparticles: Analysis of Its Anti-prostate Cancer and Antioxidant Properties
Herein, we have devised a green protocol for the biogenicmadeAu NPs mediated over natural and biological macromolecules derived from Quince (Cydoniaoblonga) seed mucilage (QSM). The intrinsic phytomolecules were utilized as effective reducing agent for the gold ions under ultrasonic conditions. They also enabled the Au NPs to stabilize inherently by capping or encapsulation. The structure of the Au NPs/QSM bio-nanocomposite was analyzed using a range of physicochemical techniques, such as elemental mapping, TEM, FE-SEM, UV-Vis spectroscopy, EDS, and ICP. In medicinal therapeutics sector on human health the cancer treatment assumes an important segment. Furthermore, the material’s biological activity was assessed by examining its antioxidant and cytotoxic characteristics against cell lines of prostate carcinoma. DPPH radical scavenging experiments were used to evaluate the antioxidant potential of Au NPs/QSM, and the resulting IC50 was determined to be 138.1 µg/mL.IC50index of the Au NPs/QSM against PC3, NCI-H660, and LNCaP cell lines were evaluated as 253, 271 and 195 µg/mL, respectively. Au NPs/QSM was found to cause a dose-dependent reduction in the viability of a malignant prostate cell line. The antioxidant properties of recent nanoparticles appear to be the cause of their anti-human prostate carcinoma activity.
期刊介绍：
The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.
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