Bhishma Karki, Abdullah Saad Alsubaie, Partha Sarkar, Manoj Sharma, Naim Ben Ali
{"title":"利用金银合金和 WS2 表面等离子体共振传感器检测皮肤癌、宫颈癌和乳腺癌","authors":"Bhishma Karki, Abdullah Saad Alsubaie, Partha Sarkar, Manoj Sharma, Naim Ben Ali","doi":"10.1007/s11468-024-02521-z","DOIUrl":null,"url":null,"abstract":"<p>Surface plasmon resonance (SPR) is used in this article to introduce a novel multilayer configuration and investigate its efficacy as a cancer detection sensor. Our proposed structure comprises an analyte-containing sensing layer underneath an alloy (Au–Ag) and a WS<sub>2</sub> layer on top. Utilizing angle interrogation for analysis and a BK7 prism set up in the Kretschmann configuration, SPR is induced. Sellmeier equations are utilized to compute reflectivity and additional parameters of the multilayer design. According to our analysis, the maximum sensitivity of 304°/RIU was achieved with alloy metal and 2*WS<sub>2</sub> layered SPR sensor configuration, which is significantly higher than recent SPR-based sensors at 662-nm wavelength. The proposed sensor measured the refractive index (RI) of the sensing medium (SM) at 1.399, which is a tiny change, and found a penetration depth (PD) of 189.79 nm. The proposed sensor performance parameters for various cancer types, including skin, cervical, and breast cancers, have been examined. The proposed SPR sensor shows a high potential for accurately detecting different biomolecules, as evidenced by the 39.33/RIU FoM achieved at 1.399 RI of SM with 37 nm thickness of alloy metal layer.</p>","PeriodicalId":736,"journal":{"name":"Plasmonics","volume":"318 1","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Detection of Skin, Cervical, and Breast Cancer Using Au–Ag Alloy and WS2-Based Surface Plasmon Resonance Sensor\",\"authors\":\"Bhishma Karki, Abdullah Saad Alsubaie, Partha Sarkar, Manoj Sharma, Naim Ben Ali\",\"doi\":\"10.1007/s11468-024-02521-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Surface plasmon resonance (SPR) is used in this article to introduce a novel multilayer configuration and investigate its efficacy as a cancer detection sensor. Our proposed structure comprises an analyte-containing sensing layer underneath an alloy (Au–Ag) and a WS<sub>2</sub> layer on top. Utilizing angle interrogation for analysis and a BK7 prism set up in the Kretschmann configuration, SPR is induced. Sellmeier equations are utilized to compute reflectivity and additional parameters of the multilayer design. According to our analysis, the maximum sensitivity of 304°/RIU was achieved with alloy metal and 2*WS<sub>2</sub> layered SPR sensor configuration, which is significantly higher than recent SPR-based sensors at 662-nm wavelength. The proposed sensor measured the refractive index (RI) of the sensing medium (SM) at 1.399, which is a tiny change, and found a penetration depth (PD) of 189.79 nm. The proposed sensor performance parameters for various cancer types, including skin, cervical, and breast cancers, have been examined. The proposed SPR sensor shows a high potential for accurately detecting different biomolecules, as evidenced by the 39.33/RIU FoM achieved at 1.399 RI of SM with 37 nm thickness of alloy metal layer.</p>\",\"PeriodicalId\":736,\"journal\":{\"name\":\"Plasmonics\",\"volume\":\"318 1\",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasmonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://doi.org/10.1007/s11468-024-02521-z\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasmonics","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1007/s11468-024-02521-z","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Detection of Skin, Cervical, and Breast Cancer Using Au–Ag Alloy and WS2-Based Surface Plasmon Resonance Sensor
Surface plasmon resonance (SPR) is used in this article to introduce a novel multilayer configuration and investigate its efficacy as a cancer detection sensor. Our proposed structure comprises an analyte-containing sensing layer underneath an alloy (Au–Ag) and a WS2 layer on top. Utilizing angle interrogation for analysis and a BK7 prism set up in the Kretschmann configuration, SPR is induced. Sellmeier equations are utilized to compute reflectivity and additional parameters of the multilayer design. According to our analysis, the maximum sensitivity of 304°/RIU was achieved with alloy metal and 2*WS2 layered SPR sensor configuration, which is significantly higher than recent SPR-based sensors at 662-nm wavelength. The proposed sensor measured the refractive index (RI) of the sensing medium (SM) at 1.399, which is a tiny change, and found a penetration depth (PD) of 189.79 nm. The proposed sensor performance parameters for various cancer types, including skin, cervical, and breast cancers, have been examined. The proposed SPR sensor shows a high potential for accurately detecting different biomolecules, as evidenced by the 39.33/RIU FoM achieved at 1.399 RI of SM with 37 nm thickness of alloy metal layer.
期刊介绍:
Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons.
Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.