用芽孢杆菌生产γ-聚谷氨酸微凝胶：工业应用和未来展望

IF 3.1 4区工程技术 Q2 POLYMER SCIENCE

Polymers for Advanced Technologies Pub Date : 2024-09-11 DOI:10.1002/pat.6565

Priti Pal, Akhilesh Kumar Singh, Prakash Kumar Sarangi, Uttam Kumar Sahoo, Harikesh B. Singh, Sanjukta Subudhi, Thangjam Anand Singh

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引用次数: 0

摘要

由芽孢杆菌属生产的γ-聚谷氨酸（γ-PGA）微凝胶具有生物降解性、生物相容性和无毒性，是一种具有多种工业应用前景的生物材料。本综述探讨了当前工业化生产 γ-PGA 微凝胶的方法，重点关注发酵条件的优化、芽孢杆菌菌株的基因工程以及下游加工技术的进步。讨论了γ-PGA 在制药、农业和环境管理方面的主要应用，强调了它在药物输送系统、生物控制剂和废水处理方面的作用。未来的展望包括通过合成生物学提高生产效率，扩大其应用范围，以及应对经济和监管方面的挑战以促进更广泛的应用。创新技术和多学科方法的整合对于γ-PGA 微凝胶的可持续发展和商业成功至关重要。

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Production of gamma‐polyglutamic acid microgel by Bacillus species: Industrial applications and future perspectives

γ‐Polyglutamic acid (γ‐PGA) microgel, produced by Bacillus spp., represents a promising biomaterial with diverse industrial applications due to its biodegradability, biocompatibility, and nontoxic nature. This review explores the current methodologies in the industrial production of γ‐PGA microgel, emphasizing the optimization of fermentation conditions, genetic engineering of Bacillus strains, and advances in downstream processing techniques. Key applications in pharmaceuticals, agriculture, and environmental management are discussed, highlighting its role in drug delivery systems, as a biocontrol agent, and in wastewater treatment. Future perspectives include enhancing production efficiency through synthetic biology, expanding its application scope, and addressing economic and regulatory challenges to facilitate broader adoption. The integration of innovative technologies and multidisciplinary approaches is crucial for the sustainable development and commercial success of γ‐PGA microgel.

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来源期刊

Polymers for Advanced Technologies 工程技术-高分子科学

CiteScore

6.20

自引率

5.90%

发文量

337

审稿时长

2.1 months

期刊介绍： Polymers for Advanced Technologies is published in response to recent significant changes in the patterns of materials research and development. Worldwide attention has been focused on the critical importance of materials in the creation of new devices and systems. It is now recognized that materials are often the limiting factor in bringing a new technical concept to fruition and that polymers are often the materials of choice in these demanding applications. A significant portion of the polymer research ongoing in the world is directly or indirectly related to the solution of complex, interdisciplinary problems whose successful resolution is necessary for achievement of broad system objectives. Polymers for Advanced Technologies is focused to the interest of scientists and engineers from academia and industry who are participating in these new areas of polymer research and development. It is the intent of this journal to impact the polymer related advanced technologies to meet the challenge of the twenty-first century. Polymers for Advanced Technologies aims at encouraging innovation, invention, imagination and creativity by providing a broad interdisciplinary platform for the presentation of new research and development concepts, theories and results which reflect the changing image and pace of modern polymer science and technology. Polymers for Advanced Technologies aims at becoming the central organ of the new multi-disciplinary polymer oriented materials science of the highest scientific standards. It will publish original research papers on finished studies; communications limited to five typewritten pages plus three illustrations, containing experimental details; review articles of up to 40 pages; letters to the editor and book reviews. Review articles will normally be published by invitation. The Editor-in-Chief welcomes suggestions for reviews.