为什么说具有动态可转换特性的生物聚合物微凝胶是培养干细胞的最佳工具箱？

IF 4.3 3区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials Interfaces Pub Date : 2024-08-17 DOI:10.1002/admi.202400354

Berna Özkale, Oliver Lieleg

{"title":"为什么说具有动态可转换特性的生物聚合物微凝胶是培养干细胞的最佳工具箱？","authors":"Berna Özkale, Oliver Lieleg","doi":"10.1002/admi.202400354","DOIUrl":null,"url":null,"abstract":"In this short perspective article, it is asked why – different from their macroscopic bulk counterparts – biopolymer‐based microgels with dynamically switchable mechanical properties are basically non‐existent. The article pinpoints why such dynamic control over the viscoelasticity of microgels would be desirable for the encapsulation of stem cells, how switchable mechanical properties may be achievable in biopolymer‐based microgel systems, and what pitfalls and issues need to be addressed to realize such a complex, engineered microenvironment for cells.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"122 1","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Why Biopolymer Microgels with Dynamically Switchable Properties Would be a Great Tool‐Box for the Cultivation of Stem Cells\",\"authors\":\"Berna Özkale, Oliver Lieleg\",\"doi\":\"10.1002/admi.202400354\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this short perspective article, it is asked why – different from their macroscopic bulk counterparts – biopolymer‐based microgels with dynamically switchable mechanical properties are basically non‐existent. The article pinpoints why such dynamic control over the viscoelasticity of microgels would be desirable for the encapsulation of stem cells, how switchable mechanical properties may be achievable in biopolymer‐based microgel systems, and what pitfalls and issues need to be addressed to realize such a complex, engineered microenvironment for cells.\",\"PeriodicalId\":115,\"journal\":{\"name\":\"Advanced Materials Interfaces\",\"volume\":\"122 1\",\"pages\":\"\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-08-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Materials Interfaces\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1002/admi.202400354\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Materials Interfaces","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1002/admi.202400354","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

在这篇简短的视角文章中，我们提出了一个问题：为什么与宏观上的大块微凝胶不同，具有动态可切换机械特性的生物聚合物基微凝胶基本上不存在。文章指出了为什么这种对微凝胶粘弹性的动态控制是干细胞封装所需要的，如何在基于生物聚合物的微凝胶系统中实现可切换的机械特性，以及实现这种复杂、工程化的细胞微环境需要解决哪些陷阱和问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Why Biopolymer Microgels with Dynamically Switchable Properties Would be a Great Tool‐Box for the Cultivation of Stem Cells

查看原文本刊更多论文

Why Biopolymer Microgels with Dynamically Switchable Properties Would be a Great Tool‐Box for the Cultivation of Stem Cells

In this short perspective article, it is asked why – different from their macroscopic bulk counterparts – biopolymer‐based microgels with dynamically switchable mechanical properties are basically non‐existent. The article pinpoints why such dynamic control over the viscoelasticity of microgels would be desirable for the encapsulation of stem cells, how switchable mechanical properties may be achievable in biopolymer‐based microgel systems, and what pitfalls and issues need to be addressed to realize such a complex, engineered microenvironment for cells.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Advanced Materials Interfaces CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

8.40

自引率

5.60%

发文量

1174

审稿时长

1.3 months

期刊介绍： Advanced Materials Interfaces publishes top-level research on interface technologies and effects. Considering any interface formed between solids, liquids, and gases, the journal ensures an interdisciplinary blend of physics, chemistry, materials science, and life sciences. Advanced Materials Interfaces was launched in 2014 and received an Impact Factor of 4.834 in 2018. The scope of Advanced Materials Interfaces is dedicated to interfaces and surfaces that play an essential role in virtually all materials and devices. Physics, chemistry, materials science and life sciences blend to encourage new, cross-pollinating ideas, which will drive forward our understanding of the processes at the interface. Advanced Materials Interfaces covers all topics in interface-related research: Oil / water separation, Applications of nanostructured materials, 2D materials and heterostructures, Surfaces and interfaces in organic electronic devices, Catalysis and membranes, Self-assembly and nanopatterned surfaces, Composite and coating materials, Biointerfaces for technical and medical applications. Advanced Materials Interfaces provides a forum for topics on surface and interface science with a wide choice of formats: Reviews, Full Papers, and Communications, as well as Progress Reports and Research News.