我们是否更接近实现偏头痛治疗的精准医学?叙述性综述。

IF 5 2区 医学 Q1 CLINICAL NEUROLOGY
Keiko Ihara,Francesco Casillo,Ahmed Dahshan,Hamit Genç,Asel Jusupova,Kunduz Karbozova,Wonwoo Lee,Yi Chia Liaw,Theodoros Mavridis,Hong-Kyun Park,Burcu Polat,Triin Helin Unt,Nina Vashchenko,Aisha Zhantleuova,Patricia Pozo-Rosich,Todd J Schwedt
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引用次数: 0

摘要

背景 "精准医疗 "一词包括优化诊断和结果预测的策略,以及根据患者的独特特征为其量身定制治疗方案的策略。近年来,随着多方面数据集和此类数据建模策略的日益普及,精准医疗越来越成为可能。由于并非所有偏头痛患者都能对偏头痛治疗做出普遍反应,因此偏头痛领域尤其需要精准医疗。方法在PubMed上搜索2005年至2024年1月期间发表的以人类参与者为对象的英文文章,找出报道有助于偏头痛精准医疗研究的文章。结果已发表的研究调查了与发作性或慢性偏头痛患者的急性和预防性治疗反应相关的特征,如非甾体类抗炎药、曲普坦、onabotulinumtoxinA 和抗降钙素基因相关肽单克隆抗体。有证据表明,临床、遗传、表观遗传、蛋白质组、生理和脑成像特征可能与偏头痛的治疗结果有关,但这些发现显然存在不一致之处。为了实现偏头痛治疗的精准医疗,需要进一步开展研究,验证和扩展现有研究结果,并在临床环境中测试偏头痛治疗预测模型的准确性和价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Are we closer to achieving precision medicine for migraine treatment? A narrative review.
BACKGROUND The term 'precision medicine' encompasses strategies to optimize diagnosis and outcome prediction and to tailor treatment for individual patients, in consideration of their unique characteristics. The greater availability of multifaceted datasets and strategies to model such data have made precision medicine increasingly possible in recent years. Precision medicine is especially needed in the migraine field since the response to migraine treatments is not universal amongst all individuals with migraine. OBJECTIVE To provide a narrative review describing contributions to achieving precision medicine for migraine treatment. METHODS A search of PubMed for English language articles of human participants published from 2005 to January 2024 was conducted to identify articles that reported research contributing to precision medicine for migraine treatment. The published literature was categorized and summarized according to the type of data that were included: clinical phenotypes, genomics, proteomics, physiologic measures, and brain imaging. RESULTS Published studies have investigated characteristics associated with acute and preventive treatment responses, such as nonsteroidal anti-inflammatory drugs, triptans, onabotulinumtoxinA, and anti-calcitonin gene-related peptide monoclonal antibodies, in patients with episodic or chronic migraine. There is evidence that clinical, genetic, epigenetic, proteomic, physiologic, and brain imaging features might associate with migraine treatment outcomes, although inconsistencies for such findings clearly exist. CONCLUSIONS The published literature suggests that there are clinical and biological features which associate with, and might be useful for predicting, migraine treatment responses. To achieve precision medicine for migraine treatment, further research is needed that validates and expands on existing findings and tests the accuracy and value of migraine treatment prediction models in clinical settings.
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来源期刊
Cephalalgia
Cephalalgia 医学-临床神经学
CiteScore
10.10
自引率
6.10%
发文量
108
审稿时长
4-8 weeks
期刊介绍: Cephalalgia contains original peer reviewed papers on all aspects of headache. The journal provides an international forum for original research papers, review articles and short communications. Published monthly on behalf of the International Headache Society, Cephalalgia''s rapid review averages 5 ½ weeks from author submission to first decision.
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