使用 CAIPIRINHA-Dixon-TWIST 动态对比增强磁共振成像评估缺血性中风的大脑中动脉干斑炎症

IF 3.3 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging Pub Date : 2024-09-11 DOI:10.1002/jmri.29576

Junxia Niu, Yuncai Ran, Rui Chen, Yan Zhang, Yong Zhang, Qi Yang, Jingliang Cheng

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Plaque inflammation is crucial for plaque stability and urgently needs quantitative detection.PurposeTo explore the utility of Controlled Aliasing in Parallel Imaging Results in Higher Acceleration (CAIPIRINHA)‐Dixon‐Time‐resolved angiography With Interleaved Stochastic Trajectories (TWIST) (CDT) dynamic contrast‐enhanced MRI (DCE‐MRI) for evaluating MCA culprit plaque inflammation changes over stroke time and with diabetes mellitus (DM).Study TypeProspective.PopulationNinety‐four patients (51.6 ± 12.23 years, 32 females, 23 DM) with acute IS (AIS; N = 43) and non‐acute IS (non‐AIS; 14 days < stroke time ≤ 3 months; N = 51).Field Strength/Sequence3‐T, CDT DCE‐MRI and three‐dimensional (3D) Sampling Perfection with Application optimized Contrast using different flip angle Evolution (3D‐SPACE) T1‐weighted imaging (T1WI).AssessmentStroke time (from initial IS symptoms to MRI) and DM were registered. 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引用次数: 0

摘要

背景大脑中动脉（MCA）斑块是缺血性中风（IS）的主要病因。目的探索 "平行成像结果中的可控差分加速（CAIPIRINHA）-狄克逊时间分辨血管造影与交错随机轨迹（TWIST）（CDT）"动态对比增强磁共振成像（DCE-MRI）在评估MCA罪魁祸首斑块炎症随中风时间和糖尿病（DM）的变化的实用性。研究对象94名急性IS（AIS；N = 43）和非急性IS（non-AIS；14天<；卒中时间≤3个月；N = 51）患者（51.6 ± 12.23岁，32名女性，23名DM）。场强/序列3-T、CDT DCE-MRI和使用不同翻转角进化（3D-SPACE）T1加权成像（T1WI）的三维（3D）完美采样与应用优化对比度。对于 94 个 MCA 罪魁祸首斑块，比较了有无 AIS 和 DM 组 CDT DCE-MRI 的 Ktrans 和 3D-SPACE T1WI 的增强比 (ER)。统计检验Shapiro-Wilk 检验、Bland-Altman 分析、Passing 和 Bablok 检验、独立 t 检验、Mann-Whitney U 检验、Chi-squared 检验、费雪精确检验、曲线下面积（AUC）接收者操作特征（ROC）、DeLong 检验和 Spearman 秩相关检验，P 值显著性水平为 0.05。05.结果AIS患者MCA罪魁祸首斑块的Ktrans和ER明显高于非AIS患者（Ktrans = 0.098 s-1 vs. 0.037 s-1；ER = 0.86 vs. 0.55）。Ktrans 在区分 AIS 和非 AIS 患者方面显示出更好的 AUC（0.87 vs. 0.75），与卒中时间的负相关性比 ER 更强（r = -0.60 vs. -0.34）。在 IS 和 AIS 组中，DM 患者的 Ktrans 和 ER 明显高于非 DM 患者。数据结论CDT DCE-MRI 图像可定量评估中风时间和 DM 的 MCA 肇因斑块。

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Evaluation of Middle Cerebral Artery Culprit Plaque Inflammation in Ischemic Stroke Using CAIPIRINHA‐Dixon‐TWIST Dynamic Contrast‐Enhanced Magnetic Resonance Imaging

BackgroundMiddle cerebral artery (MCA) plaques are a leading cause of ischemic stroke (IS). Plaque inflammation is crucial for plaque stability and urgently needs quantitative detection.PurposeTo explore the utility of Controlled Aliasing in Parallel Imaging Results in Higher Acceleration (CAIPIRINHA)‐Dixon‐Time‐resolved angiography With Interleaved Stochastic Trajectories (TWIST) (CDT) dynamic contrast‐enhanced MRI (DCE‐MRI) for evaluating MCA culprit plaque inflammation changes over stroke time and with diabetes mellitus (DM).Study TypeProspective.PopulationNinety‐four patients (51.6 ± 12.23 years, 32 females, 23 DM) with acute IS (AIS; N = 43) and non‐acute IS (non‐AIS; 14 days < stroke time ≤ 3 months; N = 51).Field Strength/Sequence3‐T, CDT DCE‐MRI and three‐dimensional (3D) Sampling Perfection with Application optimized Contrast using different flip angle Evolution (3D‐SPACE) T1‐weighted imaging (T1WI).AssessmentStroke time (from initial IS symptoms to MRI) and DM were registered. For 94 MCA culprit plaques, Ktrans from CDT DCE‐MRI and enhancement ratio (ER) from 3D‐SPACE T1WI were compared between groups with and without AIS and DM.Statistical TestsShapiro–Wilk test, Bland–Altman analysis, Passing and Bablok test, independent t‐test, Mann–Whitney U test, Chi‐squared test, Fisher's exact test, receiver operating characteristics (ROC) with the area under the curve (AUC), DeLong's test, and Spearman rank correlation test with the P‐value significance level of 0.05.ResultsKtrans and ER of MCA culprit plaques were significantly higher in AIS than non‐AIS patients (Ktrans = 0.098 s−1 vs. 0.037 s−1; ER = 0.86 vs. 0.55). Ktrans showed better AUC for distinguishing AIS from non‐AIS patients (0.87 vs. 0.75) and stronger negative correlation with stroke time than ER (r = −0.60 vs. −0.34). DM patients had significantly higher Ktrans and ER than non‐DM patients in IS and AIS groups.Data ConclusionImaging by CDT DCE‐MRI may allow to quantitatively evaluate MCA culprit plaques over stroke time and DM.Evidence Level2Technical EfficacyStage 2

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来源期刊

Journal of Magnetic Resonance Imaging 医学-核医学

CiteScore

9.70

自引率

6.80%

发文量

494

审稿时长

2 months

期刊介绍： The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.