来自胰曲霉真菌 BTBU20220155 的曲霉萜烯 A-C

IF 4.2 2区生物学 Q2 MICROBIOLOGY

Journal of Fungi Pub Date : 2024-08-27 DOI:10.3390/jof10090611

Xinjun Zhang, Fuhang Song, Jiahui Han, Long Wang, Linlin Ma, Xiuli Xu

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引用次数: 0

摘要

三种新的美拉特萜类化合物--天冬氨萜 A-C (1-3)，以及之前报道过的八种天然产物--天冬氨萜 I (4)、(2′E,4′E,6′E)-6-(1′-carboxyocta-2′,4′,6′-triene)-9-hydroxydrim-7-ene-11,12-olide (5), (2′E,4′E,(2′E，4′E，6′E)-6-(1′-羧基辛-2′，4′，6′-三烯)-11,12-环氧-9,11-二羟基屈-7-烯(6)，cinereain(7)，carnequinazolines A 和 B(8 和 9)、卡尼霉素 B（10）和链霉素（11）是从胰曲霉菌（Aspergillus insuetus，菌株 BTBU20220155）中分离出来的。这些化合物的结构是根据光谱技术确定的，包括一维和二维核磁共振、HRESIMS 和 ECD 实验。体外抗菌评价显示，化合物 5 和 11 对白色念珠菌具有抑制活性，最低抑制浓度（MIC）分别为 12.5 和 25 μg/mL。这些研究结果表明，A. insuetus 是一种具有生物活性的天然产品，有望应用于抗真菌治疗。

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Asperinsuterpenes A–C from the Fungus Aspergillus insuetus BTBU20220155

Three new meroterpenoids, asperinsuterpenes A–C (1–3), and eight previously reported natural products, namely asnovolin I (4), (2′E,4′E,6′E)-6-(1′-carboxyocta-2′,4′,6′-triene)-9-hydroxydrim-7-ene-11,12-olide (5), (2′E,4′E,6′E)-6-(1′-carboxyocta-2′,4′,6′-triene)-11,12-epoxy-9,11-dihydroxydrim-7-ene (6), cinereain (7), carnequinazolines A and B (8 and 9), carnemycin B (10), and stromemycin (11) were isolated from the fungus Aspergillus insuetus, strain BTBU20220155. The structures of the compounds were determined based on spectroscopic techniques, including 1D and 2D NMR, HRESIMS, and ECD experiments. The in vitro antimicrobial evaluation revealed that compounds 5 and 11 exhibited inhibitory activity against Candida albicans, with minimum inhibitory concentration (MIC) values of 12.5 and 25 μg/mL, respectively. These findings suggest that A. insuetus is a promising source of bioactive natural products with potential applications in antifungal therapy.

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来源期刊

Journal of Fungi Medicine-Microbiology (medical)

CiteScore

6.70

自引率

14.90%

发文量

1151

审稿时长

11 weeks

期刊介绍： Journal of Fungi (ISSN 2309-608X) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to pathogenic fungi, fungal biology, and all other aspects of fungal research. The journal publishes reviews, regular research papers, and communications in quarterly issues. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on paper length. Full experimental details must be provided so that the results can be reproduced.