深度学习辅助测量视网膜外层指标作为遗传性视网膜变性的生物标记：机遇与挑战。

IF 3 2区医学 Q1 OPHTHALMOLOGY

Current Opinion in Ophthalmology Pub Date : 2024-08-29 DOI:10.1097/icu.0000000000001088

Mark E Pennesi,Yi-Zhong Wang,David G Birch

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引用次数: 0

摘要

综述评估光感受器缺失是评估遗传性视网膜变性（IRDs）的一种直接方法。评估光感受器缺失是评估遗传性视网膜变性（IRDs）的一种直接方法。视网膜外层结构，包括核外层、椭圆形区、感光体外节段和RPE，是IRD的潜在结构生物标志物。关于结构与功能的关系，可能还需要做更多的工作。

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Deep learning aided measurement of outer retinal layer metrics as biomarkers for inherited retinal degenerations: opportunities and challenges.

PURPOSE OF REVIEW The purpose of this review was to provide a summary of currently available retinal imaging and visual function testing methods for assessing inherited retinal degenerations (IRDs), with the emphasis on the application of deep learning (DL) approaches to assist the determination of structural biomarkers for IRDs. RECENT FINDINGS (clinical trials for IRDs; discover effective biomarkers as endpoints; DL applications in processing retinal images to detect disease-related structural changes). SUMMARY Assessing photoreceptor loss is a direct way to evaluate IRDs. Outer retinal layer structures, including outer nuclear layer, ellipsoid zone, photoreceptor outer segment, RPE, are potential structural biomarkers for IRDs. More work may be needed on structure and function relationship.

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来源期刊

Current Opinion in Ophthalmology 医学-眼科学

CiteScore

6.80

自引率

5.40%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Ophthalmology is an indispensable resource featuring key up-to-date and important advances in the field from around the world. With renowned guest editors for each section, every bimonthly issue of Current Opinion in Ophthalmology delivers a fresh insight into topics such as glaucoma, refractive surgery and corneal and external disorders. With ten sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, clinicians and other healthcare professionals alike.