用于稳定股骨颈骨折的镁合金仿生套管螺钉的生物力学优化：有限元分析

IF 4.3 3区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Frontiers in Bioengineering and Biotechnology Pub Date : 2024-08-30 DOI:10.3389/fbioe.2024.1448527

Yunwei Cui, Kai Ding, Hongzhi Lv, Xiaodong Cheng, Zixi Fan, Dacheng Sun, Yifan Zhang, Wei Chen, Yingze Zhang

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引用次数: 0

摘要

目的先前的研究设计了镁合金仿生套管螺钉（MABCS），以促进股骨颈骨折的皮质-骨水泥双相愈合。主要目的是分析符合扭转标准的孔径，并进一步分析稳定股骨颈骨折的最佳孔和植入方向。方法MABCS设计的仿生孔的螺钉直径小于20%，符合金属螺钉的扭转标准。通过 Abaqus 6.14 软件模拟骨折愈合的各个阶段，确定仿生孔大小（5%、10%、15% 和 20%）和植入方向（0°、45°、90° 和 135°）的最佳生物力学环境，利用 MABCS 修复股骨颈骨折。与直径为 5%、15% 和 20% 的仿生套管螺钉相比，带有仿生孔且螺钉直径为 10%的 MABCS 可提供最佳的应力分布。此外，与螺钉直径为 5%、15% 和 20% 的 MABCS 固定模型相比，具有 10%仿生孔的套管螺钉固定模型具有最佳的骨应力分布和更好的内固定效果。这项研究为进一步优化仿生套管螺钉提供了生物力学基础。

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Biomechanical optimization of the magnesium alloy bionic cannulated screw for stabilizing femoral neck fractures: a finite element analysis

PurposesThe magnesium alloy bionic cannulated screw (MABCS) was designed in a previous study promoting cortical–cancellous biphasic healing of femoral neck fractures. The main purpose was to analyze the bore diameters that satisfy the torsion standards and further analyze the optimal pore and implantation direction for stabilizing femoral neck fractures.MethodsThe MABCS design with bionic holes with a screw diameter of less than 20% met the torsion standard for metal screws. The MABCS was utilized to repair the femoral neck fracture via Abaqus 6.14 software, which simulated the various stages of fracture healing to identify the optimal biomechanical environment for bionic hole size (5%, 10%, 15%, and 20%) and implantation direction (0°, 45°, 90°, and 135°).ResultsThe stress distribution of the MABCS fracture fixation model is significantly improved with an implantation orientation of 90°. The MABCS with a bionic hole and a screw diameter of 10% provides optimal stress distribution compared with the bionic cannulated screw with diameters of 5%, 15%, and 20%. In addition, the cannulated screw fixation model with a 10% bionic hole size has optimal bone stress distribution and better internal fixation than the MABCS fixation models with 5%, 15%, and 20% screw diameters.ConclusionIn summary, the MABCS with 10% screw diameter bionic holes has favorable biomechanical characteristics for stabilizing femoral neck fractures. This study provides a biomechanical foundation for further optimization of the bionic cannulated screw.

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来源期刊

Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering

CiteScore

8.30

自引率

5.30%

发文量

2270

审稿时长

12 weeks

期刊介绍： The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.