病例报告：打破中枢神经系统免疫特权：TNFα 抑制剂引发类风湿性关节炎患者无菌性脑膜炎

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-09-10 DOI:10.3389/fimmu.2024.1432360

Benedetta Kassabian, Monica Facco, Alessandro Miscioscia, Samuela Carraro, Francesca Rinaldi, Paolo Gallo, Marco Puthenparampil

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引用次数: 0

摘要

血脑屏障功能障碍可能是由外周炎症引起的。TNFα 抑制剂（TNF-αi）偶尔会与多种神经系统免疫介导疾病相关。然而，包括类风湿性关节炎（RA）在内的全身性自身免疫性疾病患者可能容易进一步发展为器官特异性自身免疫，包括中枢神经系统（CNS）自身免疫。在此，我们报告了一例受类风湿关节炎影响并接受依那西普治疗的患者突然出现局灶性神经系统症状的病例。报告的脑脊液、磁共振成像（MRI）和正电子发射断层扫描（PET）/MRI结果支持TNF-αi相关性无菌性脑膜炎的诊断。

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Case report: Breaking CNS immuno-privilege: TNFα-inhibitor triggers aseptic meningitis in a patient with rheumatoid arthritis

Blood-brain barrier dysfunction might be driven by peripheral inflammation. TNFα inhibitors (TNF-αi) are occasionally associated with a wide spectrum of neurological immuno-mediated disorders. However, patients with systemic autoimmune disorders, including rheumatoid arthritis (RA), might be prone to develop further organ-specific, including central nervous system (CNS), autoimmunity. Here we report the case of a patient, affected by RA and treated with etanercept, who suddenly developed focal neurological symptoms. Cerebrospinal fluid, magnetic resonance imaging (MRI), and positron emission tomography (PET)/MRI findings are reported and support the diagnosis of TNF-αi -associated aseptic meningitis.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.