泵后胆囊炎的已知与未知：关于类固醇反应性强的病例报告，暗示隐性神经炎症

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-09-10 DOI:10.3389/fimmu.2024.1458022

Muhammad Iqbal, Muizz Zaman, Niranjan Ojha, Yung-Tian A. Gau, Eufrosina I. Young

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引用次数: 0

摘要

泵后舞蹈症（PPC）的特点是在心肺旁路（CPB）手术后出现舞蹈状运动。PPC 几乎只发生在儿童身上，其病理生理学仍不清楚。在此，我们介绍了一例牛主动脉瓣置换术（AVR）后出现的主动脉瓣关闭不全的成人病例，该病例对类固醇的反应剧烈且具有可重复性，表明存在隐匿性神经炎症。这一观察结果表明，在某些亚组的多发性冠状动脉硬化症中存在一种新的潜在机制，而多发性冠状动脉硬化症很可能是一种异质性疾病。对多发性硬化症病理机制的进一步研究可为治疗这种无症状、仅受控制的病症提供启示。

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The known and unknown of post-pump chorea: a case report on robust steroid responsiveness implicating occult neuroinflammation

Post-pump chorea (PPC) is characterized by the development of choreiform movements following cardiopulmonary bypass (CPB) surgery. PPC occurs almost exclusively in children, and its pathophysiology remains unclear. Here we present an adult case of PPC after bovine aortic valve replacement (AVR) which exhibited dramatic and reproducible response to steroid, suggesting the presence of occult neuroinflammation. This observation suggests a novel underlying mechanism in certain subgroups of PPC, which is likely a heterogeneous condition to start with. Further research into the pathomechanisms of PPC could offer insights into managing this otherwise symptomatic control-only condition.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.