基于双金属 MOFs 的电极用于同时电化学检测肾上腺素和去甲肾上腺素

IF 3.1 4区工程技术 Q2 ELECTROCHEMISTRY

Journal of The Electrochemical Society Pub Date : 2024-09-04 DOI:10.1149/1945-7111/ad6c80

Charlin Soosaimanickam, Kathiresan Murugavel, Subbiah Alwarappan

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引用次数: 0

摘要

我们设计了一种 Co-Ni/BTC/4,4′-BiPy 双金属金属有机框架（MOFs）作为电化学检测肾上腺素和去甲肾上腺素的电极材料。双金属 MOFs 是通过溶热法合成的。随后，用 BTC 和富含胺的 4,4′-BiPy 对双金属 MOFs 进行修饰，通过非共价的 π-π 相互作用改善电荷转移动力学。该修饰电极被用作同时电化学检测肾上腺素和去甲肾上腺素的传感平台。经 MOFs 修饰的平台的线性范围为 10-50 μM，检出限分别为 0.724 μM ± 0.128（N = 3）和 0.815 μM ± 0.124（N = 3），灵敏度分别为 0.583 和 0.505 μA μM-1 cm-2，对应于肾上腺素和去甲肾上腺素的检测。最后，在添加了已知浓度的肾上腺素和去甲肾上腺素的血液和尿液样本中对电化学传感器进行了测试。结果证实，所提议的平台可用于检测临床样本中的肾上腺素和去甲肾上腺素。

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Bimetallic MOFs-Based Electrodes for the Simultaneous Electrochemical Detection of Epinephrine and Nor-Epinephrine

We designed a bi-metallic Co-Ni/BTC/4,4′-BiPy metal organic frameworks (MOFs) as an electrode material for the electrochemical detection of epinephrine and nor-epinephrine. The bi-metallic MOFs were synthesized by a solvothermal method. Following this, the bimetallic MOFs were modified with BTC and amine rich 4,4′-BiPy to improve charge transfer kinetics through non-covalent π–π interaction. This modified electrode was employed as a sensing platform for the simultaneous electrochemical detection of epinephrine and nor-epinephrine. The MOFs modified platform exhibited a 10–50 μM linear range with a limit of detection of 0.724 μM ± 0.128 (N = 3) and 0.815 μM ± 0.124 (N = 3), a sensitivity of 0.583 and 0.505 μA μM⁻¹ cm⁻² corresponding to epinephrine and nor-epinephrine detection. Finally, the electrochemical sensor was tested in blood and urine samples spiked with known concentrations of epinephrine and nor-epinephrine. Results confirmed the usefulness of the proposed platform for the detection of epinephrine and nor-epinephrine in clinical samples.

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来源期刊

Journal of The Electrochemical Society 工程技术-电化学

CiteScore

7.20

自引率

12.80%

发文量

1369

审稿时长

1.5 months

期刊介绍： The Journal of The Electrochemical Society (JES) is the leader in the field of solid-state and electrochemical science and technology. This peer-reviewed journal publishes an average of 450 pages of 70 articles each month. Articles are posted online, with a monthly paper edition following electronic publication. The ECS membership benefits package includes access to the electronic edition of this journal.