游离脂肪酸与美国成年人的死亡率:美国国家健康与营养调查 (NHANES) 报告

IF 3.9 2区 医学 Q2 NUTRITION & DIETETICS
Meng Li, Lijing Zhang, Bi Huang, Yang Liu, Yang Chen, Gregory Y. H. Lip
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引用次数: 0

摘要

游离脂肪酸(FFAs)与死亡风险之间的关系仍不明确。很少有前瞻性研究探讨特定游离脂肪酸(而非总浓度)对长期健康结果的影响。在一项大型、多样化、具有全国代表性的美国成年人样本中,评估不同的饱和脂肪酸与全因死亡率和心血管死亡率之间的相关性,并研究不同的饱和脂肪酸可能如何调节这种相关性。这项队列研究纳入了 2011 年至 2014 年美国国家健康与营养调查 (NHANES) 中的不饱和脂肪酸 (USFA) 组和饱和脂肪酸 (SFA) 组,并提供血液样本以检测脂肪酸水平。利用已知风险因素的 Cox 回归分析进行了多重模型校准,以探讨脂肪酸与全因死亡率和心血管死亡率之间的关系。USFA组共纳入3 719人,中位随访时间为6.7年(5.8-7.8年)。在SFA组中,我们纳入了3900人,中位随访时间为6.9年(5.9-8年)。在 USFA 组中,肉豆蔻油酸(14:1 n-5)(危险比 (HR) 1.02 [1.006-1.034]; P = 0.004)、棕榈油酸(16:1 n-7)(HR 1.001 [1.001-1.002]; P < 0.001)、顺式长春花酸(18:1 n-7)(HR 1.006 [1.003-1.009]; P < 0.001)、神经酸(24:1 n-9)(HR 1.007 [1.002-1.012]; P = 0.003)、二十碳三烯酸(20:3 n-9)(HR 1.027 [1.009-1.046]; P = 0.003)、二十二碳四烯酸(22:4 n-6)(HR 1.024 [1.012-1.036]; P < 0.001)和二十二碳五烯酸(22:5 n-6)(HR 1.019 [1.006-1.032]; P = 0.005)与全因死亡率呈正相关,而二十二碳六烯酸(22:6 n-3)的全因死亡风险在统计学上较低(HR 0.998 [0.996-0.999]; P = 0.007)。在 SFA 组中,棕榈酸(16:0)的全因死亡风险较高(HR 1.00 [1.00-1.00];P = 0.022),而三聚氰酸(23:0)(HR 0.975 [0.959-0.991];P = 0.002)和木质酸(24:0)(HR 0.992 [0.984-0.999];P = 0.036)的全因死亡风险较低。除了 23:0 和 24:0,上述其他脂肪酸与全因死亡风险呈线性相关。在这个具有全国代表性的美国成年人队列中,一些不同的反式脂肪酸与全因死亡风险有显著关联。达到特定反式脂肪酸的最佳浓度可能会降低全因死亡风险,但在心血管死亡方面却没有观察到这种益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Free fatty acids and mortality among adults in the United States: a report from US National Health and Nutrition Examination Survey (NHANES)
The relationship between free fatty acids (FFAs) and the risk of mortality remains unclear. There is a scarcity of prospective studies examining the associations between specific FFAs, rather than total concentrations, of their effect on long-term health outcomes. To evaluate the correlation between different FFAs and all-cause and cardiovascular mortality in a large, diverse, nationally representative sample of adults in the US, and examine how different FFAs may mediate this association. This cohort study included unsaturated fatty acids (USFA) and saturated fatty acids (SFA) groups in the US National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014 and provided blood samples for FFAs levels. Multiple model calibration was performed using Cox regression analysis for known risk factors to explore the associations between FFAs and all-cause and cardiovascular mortality. In the group of USFA, 3719 people were included, median follow-up, 6.7 years (5.8–7.8 years). In the SFA group, we included 3900 people with a median follow-up, 6.9 years (5.9-8 years). In the USFA group, myristoleic acid (14:1 n-5) (hazard ratio (HR) 1.02 [1.006–1.034]; P = 0.004), palmitoleic acid (16:1 n-7) (HR 1.001 [1.001–1.002]; P < 0.001), cis-vaccenic acid (18:1 n-7) (HR 1.006 [1.003–1.009]; P < 0.001), nervonic acid (24:1 n-9) (HR 1.007 [1.002–1.012]; P = 0.003), eicosatrienoic acid (20:3 n-9) (HR 1.027 [1.009–1.046]; P = 0.003), docosatetraenoic acid (22:4 n-6) (HR 1.024 [1.012–1.036]; P < 0.001), and docosapentaenoic acid (22:5 n-6) (HR 1.019 [1.006–1.032]; P = 0.005) were positively associated with the all-cause mortality, while docosahexaenoic acid (22:6 n-3) had a statistically lower risk of all-cause mortality (HR 0.998 [0.996–0.999]; P = 0.007). Among the SFA group, palmitic acid (16:0) demonstrated a higher risk of all-cause mortality (HR 1.00 [1.00–1.00]; P = 0.022), while tricosanoic acid (23:0) (HR 0.975 [0.959–0.991]; P = 0.002) and lignoceric acid (24:0) (HR 0.992 [0.984–0.999]; P = 0.036) were linked to a lower risk of all-cause mortality. Besides 23:0 and 24:0, the other FFAs mentioned above were linearly associated with the risks of all-cause mortality. In this nationally representative cohort of US adults, some different FFAs exhibited significant associations with risk of all-cause mortality. Achieving optimal concentrations of specific FFAs may lower this risk of all-cause mortality, but this benefit was not observed in regards to cardiovascular mortality.
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来源期刊
Nutrition & Metabolism
Nutrition & Metabolism 医学-营养学
CiteScore
8.40
自引率
0.00%
发文量
78
审稿时长
4-8 weeks
期刊介绍: Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.
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