Soumyadeep Bhaumik, Deepti Beri, Vishal Santra, Maya Gopalakrishnan, Mohammad Abul Faiz, Paula R Williamson, Mike Clarke, Sanjib Kumar Sharma, Jagnoor Jagnoor
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Subsequently, meetings, consultations and workshops were organised to reach further consensus. We defined the consensus criteria a priori. Results Overall, 72 and 61 people, including patients and the public, participated in round I and round II of the Delphi, respectively. Consensus COSs (including definition and time points) were developed for interventions that prevent adverse reaction to snake antivenom (three outcomes), specifically manage neurotoxic manifestations (five outcomes), specifically manage haematological manifestations (five outcomes) and those that act against snake venom (seven) outcomes. A priori criteria for inclusion in COS were not met for COS on interventions for management of the bitten part. Conclusion The COS contributes to improving research efficiency by standardising outcome measurement in South Asia. It also provides methodological insights for future development of COS, beyond snakebite. 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引用次数: 0
摘要
背景2019年世界卫生组织减少蛇咬伤负担战略强调需要促进蛇咬伤治疗研究。核心结果集(COS)是一份共识性的最小结果列表,用于衡量特定条件下的研究结果。南亚是蛇咬伤负担最重的地区,我们旨在为该地区的蛇咬伤研究制定一套核心结果集。方法 我们利用系统性结果回顾中的数据制定了一份长长的结果清单,并通过两轮在线德尔菲调查对这些结果进行评分,调查对象包括医疗服务提供者、患者和公众,以及潜在的 COS 用户,从而为南亚地区的蛇咬治疗干预研究制定出针对五个干预组的 COS。随后,我们组织了会议、咨询和研讨会,以进一步达成共识。我们事先确定了共识标准。结果 包括患者和公众在内,分别有 72 人和 61 人参加了德尔菲第一轮和第二轮讨论。针对预防蛇毒抗蛇毒血清不良反应的干预措施(3 项结果)、专门处理神经毒性表现的干预措施(5 项结果)、专门处理血液学表现的干预措施(5 项结果)以及对抗蛇毒的干预措施(7 项结果),我们制定了共识 COS(包括定义和时间点)。关于被咬部位处理干预措施的 COS 不符合纳入 COS 的先验标准。结论 通过对南亚地区的结果测量进行标准化,COS 有助于提高研究效率。它还为蛇咬伤以外的 COS 的未来发展提供了方法上的启示。所有与研究相关的数据都包含在文章中或作为在线补充信息上传。与研究相关的数据在论文或附录中列出。
Core outcome set for intervention research on snakebite envenomation in South Asia
Background The 2019 WHO strategy to reduce snakebite burden emphasises the need for fostering research on snakebite treatments. A core outcome set (COS) is a consensus minimal list of outcomes that should be measured in research on a particular condition. We aimed to develop a COS for snakebite research in South Asia, the region with the highest burden. Methods We used data from a systematic review of outcomes to develop a long list of outcomes which were rated in two rounds of online Delphi survey with healthcare providers, patients and the public, and potential COS users to develop a COS for intervention research on snakebite treatments in South Asia for five intervention groups. Subsequently, meetings, consultations and workshops were organised to reach further consensus. We defined the consensus criteria a priori. Results Overall, 72 and 61 people, including patients and the public, participated in round I and round II of the Delphi, respectively. Consensus COSs (including definition and time points) were developed for interventions that prevent adverse reaction to snake antivenom (three outcomes), specifically manage neurotoxic manifestations (five outcomes), specifically manage haematological manifestations (five outcomes) and those that act against snake venom (seven) outcomes. A priori criteria for inclusion in COS were not met for COS on interventions for management of the bitten part. Conclusion The COS contributes to improving research efficiency by standardising outcome measurement in South Asia. It also provides methodological insights for future development of COS, beyond snakebite. All data relevant to the study are included in the article or uploaded as online supplemental information. Data relevant to the study are either presented in the paper or in the appendix.
期刊介绍:
Since its inception in 1995, Injury Prevention has been the pre-eminent repository of original research and compelling commentary relevant to this increasingly important field. An international peer reviewed journal, it offers the best in science, policy, and public health practice to reduce the burden of injury in all age groups around the world. The journal publishes original research, opinion, debate and special features on the prevention of unintentional, occupational and intentional (violence-related) injuries. Injury Prevention is online only.