了解边缘性卵巢肿瘤分子机制的进展

IF 3.9 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Frontiers in Molecular Biosciences Pub Date : 2024-08-30 DOI:10.3389/fmolb.2024.1429852

Shiying Chen, Li Huang, Meili Liang, Yajing Xie, Zhimei Zhou, Yumin Ke, Zhuna Wu

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引用次数: 0

摘要

边界卵巢肿瘤（BOTs）是卵巢上皮肿瘤的一种特殊类型，介于良性肿瘤和恶性肿瘤之间，恶性可能性较低。由于这类肿瘤的早期症状相对隐蔽，临床诊断并不容易。本研究探讨了临床检测方法的进展，并全面概述了近年来与BOTs发病相关的细胞迁移因子、细胞转录因子、细胞损伤修复因子、细胞周期调节因子、抑癌基因等分子及其相关机制，旨在为患者提供更灵敏、更特异、更高效的鉴别诊断和治疗方案，以改善患者的预后和生存预后。

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Advances in understanding the molecular mechanisms of borderline ovarian tumors

Borderline ovarian tumors (BOTs), which are a special type of epithelial tumor of the ovary, lie between benign and malignant tumors and have low malignant potential. Due to the fact that the early symptoms of these tumors are relatively subtle, they are not easy to diagnose clinically. This study explores advancements in clinical detection methods and provides a comprehensive overview of molecules such as cell migration factors, cell transcription factors, cell damage repair factors, cell cycle regulators, and tumor suppressor genes that are related to the development of BOTs and their related mechanisms in recent years, thus aiming to provide more sensitive, specific, and efficient differential diagnosis and treatment plans for patients to improve their prognosis and survival outcomes.

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来源期刊

Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.20

自引率

4.00%

发文量

1361

审稿时长

14 weeks

期刊介绍： Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.