铂族金属对抗寄生虫：技术现状与未来展望

IF 1.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Medicinal Chemistry Pub Date : 2024-08-26 DOI:10.2174/0115734064324855240806052735

Jose Manuel Mendez-Arriaga

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引用次数: 0

摘要

背景：在全球范围内，寄生虫病被认为是被忽视的疾病之一。临床上使用多种药物进行治疗，但由于耐药性和多重耐药性以及对新研究方向的投资较少，寄生虫病的治疗一直处于失败状态。目标：本微型综述是对使用铂族金属作为生物制剂的全面回顾。其目的是确定这些金属元素在抗寄生虫活性特定领域的实际技术水平，并确定未来发挥作用的可能性。方法：综述包括该领域的 100 多项研究成果。讨论了铂族金属化学性质与作为具有生物活性的金属配合物之间的差异。结果：这篇综述强调了铂族金属作为抗寄生虫剂治疗不同疾病的潜力。结论这篇综述将对从事寄生虫病靶向药物治疗的研究人员有所帮助。

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Platinum Group Metals against Parasites: State of the Art and Future Perspectives

Background: Globally, parasitic diseases are considered among the neglected diseases. Clinically, several drugs are used in treatment, however due to drug resistance and multidrug resistance and the low investment in new research lines, there has been a failure in the treatment of parasitic illnesses. Objectives: The present mini-review is a comprehensive review of the use of platinum group metals as biological agents. It aims to establish the actual state of the art of these metal elements in the antiparasitic activity-specific area and define the future possibilities of action. Methods: The review comprises more than 100 research works done in this field. The differences between platinum group metals chemistry and their use as metal complexes with biological activity have been discussed. Results: This review highlighted the platinum group metal's potential as an antiparasitic agent for different diseases. Conclusion: The review will be helpful for the researchers involved in targeted drugs for parasitic disease therapy.

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来源期刊

Medicinal Chemistry 医学-医药化学

CiteScore

4.30

自引率

4.30%

发文量

109

审稿时长

12 months

期刊介绍： Aims & Scope Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.