微生物角鲨烯：化妆品和制药业的可持续替代品--综述

IF 3.9 4区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Engineering in Life Sciences Pub Date : 2024-08-27 DOI:10.1002/elsc.202400003

Saseendran Shalu, Panam Kunnel Raveendranathan, Vinoth Kumar Vaidyanathan, Lars M. Blank, Andrea Germer, Palanisamy Athiyaman Balakumaran

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引用次数: 0

摘要

角鲨烯是一种天然三萜类化合物，也是微生物、植物、人类和其他动物体内类固醇和类罂粟碱的生物合成前体。角鲨烯具有抗氧化活性、皮肤高渗透性和触发免疫系统的能力等优异特性，促进了其在化妆品、营养品和医药行业的应用。由于鲨鱼是角鲨烯的主要来源，因此需要找到低成本、环保和可持续的角鲨烯商业生产替代品。这一转变促使科学家们应用生物技术的进步来研究合成角鲨烯的微生物。本综述总结了最近在各种微生物中采用新陈代谢和生物过程工程策略，通过生物技术生产这种宝贵的分子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Microbial Squalene: A Sustainable Alternative for the Cosmetics and Pharmaceutical Industry – A Review

Squalene is a natural triterpenoid and a biosynthetic precursor of steroids and hopanoids in microorganisms, plants, humans, and other animals. Squalene has exceptional properties, such as its antioxidant activity, a high penetrability of the skin, and the ability to trigger the immune system, promoting its application in the cosmetic, sustenance, and pharmaceutical industries. Because sharks are the primary source of squalene, there is a need to identify low‐cost, environment friendly, and sustainable alternatives for producing squalene commercially. This shift has prompted scientists to apply biotechnological advances to research microorganisms for synthesizing squalene. This review summarizes recent metabolic and bioprocess engineering strategies in various microorganisms for the biotechnological production of this valuable molecule.

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来源期刊

Engineering in Life Sciences 工程技术-生物工程与应用微生物

CiteScore

6.40

自引率

3.70%

发文量

审稿时长

3 months

期刊介绍： Engineering in Life Sciences (ELS) focuses on engineering principles and innovations in life sciences and biotechnology. Life sciences and biotechnology covered in ELS encompass the use of biomolecules (e.g. proteins/enzymes), cells (microbial, plant and mammalian origins) and biomaterials for biosynthesis, biotransformation, cell-based treatment and bio-based solutions in industrial and pharmaceutical biotechnologies as well as in biomedicine. ELS especially aims to promote interdisciplinary collaborations among biologists, biotechnologists and engineers for quantitative understanding and holistic engineering (design-built-test) of biological parts and processes in the different application areas.