HBr/TMSO/HFIP 介导的吡咯并[2,1-a]异喹啉化合选择性修饰

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2024-11-01 DOI:10.1002/ajoc.202400323

Yun‐Meng Li , Man Jiang , Jing Zhou , Prof. Dr. Hai‐Lei Cui

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引用次数: 0

摘要

在对吡咯并[2,1-a]异喹啉衍生物进行改性时，HBr、TMSO（四亚甲基亚砜）和 HFIP（六氟异丙醇）被分别用于溴化、二聚化和亚砜化反应。在这些过程中，HBr 用作溴源，TMSO 用作氧化剂。HFIP 在氧化二聚过程中也起着至关重要的作用。通过调整反应时间、试剂比例和加入亲核剂等参数，可以轻松控制化学选择性。

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HBr/TMSO/HFIP Mediated Chemoselective Modifications of Pyrrolo[2,1‐a]Isoquinolines

The combination of HBr, TMSO (tetramethylene sulfoxide) and HFIP (hexafluoroisopropanol) has been utilized in the modification of pyrrolo[2,1‐a]isoquinoline derivatives through bromination, dimerization and sulfenylation respectively. In these processes, HBr serves as the source of bromine and TMSO acts as an oxidant. HFIP also plays an essential role for the oxidative dimerization. Chemoselectivity can be easily controlled by adjusting the parameters such as reaction time, ratio of reagents and the addition of nucleophile.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.