Yuequn Xie, Liangen Lin, Congcong Sun, Linglong Chen, Wang Lv
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Two prediction models were developed, and model comparison was performed using the likelihood ratio test (LRT) and the Akaike Information Criterion (AIC). A total of 194 patients were included in the analysis (72.2% male). Multivariate logistic regression analysis revealed that a one-standard deviation increase of ln-transformed ALP were independently associated with poorer prognosis: ICU mortality (odds ratios (OR) = 2.49, 95% confidence interval (CI) 1.31–4.74, P = 0.005), hospital mortality (OR = 2.21, 95% CI 1.18–4.16, P = 0.014), and unfavorable neurological outcome (OR = 2.40, 95% CI 1.25–4.60, P = 0.009). The area under the ROC curve for clinical prognosis was 0.644, 0.642, and 0.639, respectively. Additionally, LRT analyses indicated that the ALP-combined model exhibited better predictive efficacy than the model without ALP. Elevated serum ALP levels upon admission were significantly associated with poorer prognosis of ALF following CA, suggesting its potential as a valuable marker for predicting prognosis in this patient population.","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between serum alkaline phosphatase and clinical prognosis in patients with acute liver failure following cardiac arrest: a retrospective cohort study\",\"authors\":\"Yuequn Xie, Liangen Lin, Congcong Sun, Linglong Chen, Wang Lv\",\"doi\":\"10.1186/s40001-024-02049-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Acute liver failure (ALF) following cardiac arrest (CA) poses a significant healthcare challenge, characterized by high morbidity and mortality rates. 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引用次数: 0
摘要
心脏骤停(CA)后的急性肝功能衰竭(ALF)是一项重大的医疗挑战,其特点是发病率和死亡率高。本研究旨在评估心脏骤停后急性肝衰竭患者血清碱性磷酸酶(ALP)水平与不良预后之间的相关性。研究利用 Dryad 数字资料库中的数据进行了回顾性分析。研究的主要结果是重症监护室(ICU)死亡率、住院死亡率和不良神经功能预后。采用多变量逻辑回归分析评估血清 ALP 水平与临床预后之间的关系。使用接收器操作者特征(ROC)曲线分析评估了预测价值。建立了两个预测模型,并使用似然比检验(LRT)和阿凯克信息准则(AIC)对模型进行比较。共有 194 名患者(72.2% 为男性)被纳入分析。多变量逻辑回归分析显示,ln 变形 ALP 的一个标准差增加与较差的预后独立相关:ICU 死亡率(几率比(OR)= 2.49,95% 置信区间 (CI) 1.31-4.74,P = 0.005)、住院死亡率(OR = 2.21,95% CI 1.18-4.16,P = 0.014)和不利的神经系统预后(OR = 2.40,95% CI 1.25-4.60,P = 0.009)。临床预后的 ROC 曲线下面积分别为 0.644、0.642 和 0.639。此外,LRT 分析表明,ALP 组合模型的预测效果优于不含 ALP 的模型。入院时血清 ALP 水平升高与 CA 后 ALF 较差的预后明显相关,这表明 ALP 有可能成为预测这类患者预后的重要标志物。
Association between serum alkaline phosphatase and clinical prognosis in patients with acute liver failure following cardiac arrest: a retrospective cohort study
Acute liver failure (ALF) following cardiac arrest (CA) poses a significant healthcare challenge, characterized by high morbidity and mortality rates. This study aims to assess the correlation between serum alkaline phosphatase (ALP) levels and poor outcomes in patients with ALF following CA. A retrospective analysis was conducted utilizing data from the Dryad digital repository. The primary outcomes examined were intensive care unit (ICU) mortality, hospital mortality, and unfavorable neurological outcome. Multivariable logistic regression analysis was employed to assess the relationship between serum ALP levels and clinical prognosis. The predictive value was evaluated using receiver operator characteristic (ROC) curve analysis. Two prediction models were developed, and model comparison was performed using the likelihood ratio test (LRT) and the Akaike Information Criterion (AIC). A total of 194 patients were included in the analysis (72.2% male). Multivariate logistic regression analysis revealed that a one-standard deviation increase of ln-transformed ALP were independently associated with poorer prognosis: ICU mortality (odds ratios (OR) = 2.49, 95% confidence interval (CI) 1.31–4.74, P = 0.005), hospital mortality (OR = 2.21, 95% CI 1.18–4.16, P = 0.014), and unfavorable neurological outcome (OR = 2.40, 95% CI 1.25–4.60, P = 0.009). The area under the ROC curve for clinical prognosis was 0.644, 0.642, and 0.639, respectively. Additionally, LRT analyses indicated that the ALP-combined model exhibited better predictive efficacy than the model without ALP. Elevated serum ALP levels upon admission were significantly associated with poorer prognosis of ALF following CA, suggesting its potential as a valuable marker for predicting prognosis in this patient population.
期刊介绍:
European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.