羧甲基壳聚糖水凝胶的医疗应用和细胞作用机制

IF 4.2 2区 化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Weronika Kruczkowska, Karol Kamil Kłosiński, Katarzyna Helena Grabowska, Julia Gałęziewska, Piotr Gromek, Mateusz Kciuk, Żaneta Kałuzińska-Kołat, Damian Kołat, Radosław A. Wach
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引用次数: 0

摘要

羧甲基壳聚糖(CMCS)水凝胶具有多种特性,适用于各种医疗应用,因此已在生物医学研究中得到广泛应用。对生物医学应用特别有价值的关键特性包括生物相容性、量身定制的类似固体的机械特性、生物可降解性、抗菌活性、保湿性和对 pH 值刺激敏感的膨胀性。这些特性具有增强愈合、促进肉芽组织形成和促进中性粒细胞迁移等优点。因此,CMCS 水凝胶是应用于生物制药、给药系统、伤口愈合、组织工程等领域的有利材料。了解 CMCS 水凝胶与生物系统之间的相互作用,重点是其对细胞行为的影响,对于充分利用其多功能性至关重要。由于人们对壳聚糖及其衍生物水凝胶在生物医学研究和应用方面的兴趣与日俱增,本综述旨在根据最新研究成果,对 CMCS 的潜在医学应用提供最新见解。此外,我们还全面阐明了这些水凝胶在医疗环境中发挥作用的细胞机制。总之,本文总结了从现有文献中收集到的宝贵数据,为羧甲基水凝胶在各种医疗环境中的进一步开发和利用提供了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Medical Applications and Cellular Mechanisms of Action of Carboxymethyl Chitosan Hydrogels
Carboxymethyl chitosan (CMCS) hydrogels have been investigated in biomedical research because of their versatile properties that make them suitable for various medical applications. Key properties that are especially valuable for biomedical use include biocompatibility, tailored solid-like mechanical characteristics, biodegradability, antibacterial activity, moisture retention, and pH stimuli-sensitive swelling. These features offer advantages such as enhanced healing, promotion of granulation tissue formation, and facilitation of neutrophil migration. As a result, CMCS hydrogels are favorable materials for applications in biopharmaceuticals, drug delivery systems, wound healing, tissue engineering, and more. Understanding the interactions between CMCS hydrogels and biological systems, with a focus on their influence on cellular behavior, is crucial for leveraging their versatility. Because of the constantly growing interest in chitosan and its derivative hydrogels in biomedical research and applications, the present review aims to provide updated insights into the potential medical applications of CMCS based on recent findings. Additionally, we comprehensively elucidated the cellular mechanisms underlying the actions of these hydrogels in medical settings. In summary, this paper recapitulates valuable data gathered from the current literature, offering perspectives for further development and utilization of carboxymethyl hydrogels in various medical contexts.
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来源期刊
Molecules
Molecules 化学-有机化学
CiteScore
7.40
自引率
8.70%
发文量
7524
审稿时长
1.4 months
期刊介绍: Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.
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