Elisabet Gómez-González, Carlos Caro, Nuria O. Núñez, Daniel González-Mancebo, Jesús D. Urbano-Gámez, Maria L. García-Martín, Manuel Ocaña
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引用次数: 0
摘要
近年来,有关高场磁共振成像(HF-MRI)的研究不断增加,旨在通过提高信噪比从而提高图像质量来提高诊断的准确性。传统的造影剂(CA)在高场磁共振成像方面有很大的局限性,因此需要开发新的造影剂。其中,最有前途的替代品是基于 Dy3+ 或 Ho3+ 化合物的造影剂。值得注意的是,镧系阳离子的高原子序数将赋予这类基于 Dy 或 Ho 的化合物较高的 X 射线衰减能力,这也将使它们能够用作 X 射线计算机断层扫描(CT)的 CA。在这项工作中,我们制备了均匀的 NaDy(WO4)2 和 NaHo(WO4)2 纳米粒子(NPs),它们在模拟生理介质的条件下可分散,对细胞无毒,符合在体内使用的主要要求。这两种 NPs 在 9.4 T 下均表现出令人满意的磁弛豫性,因此很有希望替代临床 CAs 用于高频磁共振成像。此外,在对肿瘤小鼠进行静脉注射后,两种 NPs 在 24 小时内均在肿瘤内有显著的蓄积,这归因于增强渗透性和滞留(EPR)效应的被动靶向作用。因此,我们的 NPs 适合通过高频磁共振成像检测肿瘤。最后,NaDy(WO4)2 NPs 的 X 射线衰减能力优于碘己醇(商用 CT CA),加上其较高的 r2 值,使其适合作为高频-磁共振成像和 CT 成像的双探针,这一点已在使用健康小鼠进行的体内实验中得到证实。
Sodium lanthanide tungstate-based nanoparticles as bimodal contrast agents for in vivo high-field MRI and CT imaging
Research on high-field magnetic resonance imaging (HF-MRI) has been increased in recent years, aiming to improve diagnosis accuracy by increasing the signal-to-noise ratio and hence image quality. Conventional contrast agents (CAs) have important limitations for HF-MRI, with the consequent need for the development of new CAs. Among them, the most promising alternatives are those based on Dy3+ or Ho3+ compounds. Notably, the high atomic number of lanthanide cations would bestow a high capability for X-ray attenuation to such Dy or Ho-based compounds, which would also allow them to be employed as CAs for X-ray computed tomography (CT). In this work, we have prepared uniform NaDy(WO4)2 and NaHo(WO4)2 nanoparticles (NPs), which were dispersible under conditions that mimic the physiological media and were nontoxic for cells, meeting the main requirements for their use in vivo. Both NPs exhibited satisfactory magnetic relaxivities at 9.4 T, thus making them a promising alternative to clinical CAs for HF-MRI. Furthermore, after their intravenous administration in tumor-bearing mice, both NPs exhibited significant accumulation inside the tumor at 24 h, attributable to passive targeting by the enhanced permeability and retention (EPR) effect. Therefore, our NPs are suitable for the detection of tumors through HF-MRI. Finally, NaDy(WO4)2 NPs showed a superior X-ray attenuation capability than iohexol (commercial CT CA), which, along with their high r2 value, makes them suitable as the dual-probe for both HF-MRI and CT imaging, as demonstrated by in vivo experiments conducted using healthy mice.
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices