Mahmoud Maree E. Tammam, Mohamed Farhat O. Hameed, Essam M. A. Elkaramany, Tamer A. Ali, S. S. A. Obayya
{"title":"用于生物医学应用的多功能太赫兹超材料传感器","authors":"Mahmoud Maree E. Tammam, Mohamed Farhat O. Hameed, Essam M. A. Elkaramany, Tamer A. Ali, S. S. A. Obayya","doi":"10.1007/s11468-024-02401-6","DOIUrl":null,"url":null,"abstract":"<p>In this work, we propose a THz metamaterial for biomedical applications. The full vectorial finite element method is used to design and analyze the reported biosensor. The proposed sensor is based on increasing the confinement of the electric and magnetic fields at the analyte layer at the resonance frequency. Hence, any slight variation of the optical properties of the analyte sample (typically the refractive index) can be detected. We demonstrate the potential of using the reported sensor for hemoglobin (Hb) concentration and early cancer detection. The geometrical parameters are studied to maximize the sensor sensitivity of the symmetric and asymmetric designs. An absorptivity of 0.98 is achieved at 1.1 THz, which depends on the analyte sample refractive index<b>.</b> High sensor sensitivity of 1.08 GHz/g/dL is obtained with high Q-factor of 13.2 and FWHM (full width at half maximum) of 140 GHz through hemoglobin (Hb) concentration change from 5 g/dL to 20 g/dL. Further, an average sensitivity of 556.325 GHz/RIU is realized for cancer early detection for basal cell, breast cell, Jurkat cell and Cervical cell. Therefore, the proposed design is a good candidate for biomedical applications.</p>","PeriodicalId":736,"journal":{"name":"Plasmonics","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Versatile Terahertz Metamaterial Sensor for Biomedical Applications\",\"authors\":\"Mahmoud Maree E. Tammam, Mohamed Farhat O. Hameed, Essam M. A. Elkaramany, Tamer A. Ali, S. S. A. Obayya\",\"doi\":\"10.1007/s11468-024-02401-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>In this work, we propose a THz metamaterial for biomedical applications. The full vectorial finite element method is used to design and analyze the reported biosensor. The proposed sensor is based on increasing the confinement of the electric and magnetic fields at the analyte layer at the resonance frequency. Hence, any slight variation of the optical properties of the analyte sample (typically the refractive index) can be detected. We demonstrate the potential of using the reported sensor for hemoglobin (Hb) concentration and early cancer detection. The geometrical parameters are studied to maximize the sensor sensitivity of the symmetric and asymmetric designs. An absorptivity of 0.98 is achieved at 1.1 THz, which depends on the analyte sample refractive index<b>.</b> High sensor sensitivity of 1.08 GHz/g/dL is obtained with high Q-factor of 13.2 and FWHM (full width at half maximum) of 140 GHz through hemoglobin (Hb) concentration change from 5 g/dL to 20 g/dL. Further, an average sensitivity of 556.325 GHz/RIU is realized for cancer early detection for basal cell, breast cell, Jurkat cell and Cervical cell. Therefore, the proposed design is a good candidate for biomedical applications.</p>\",\"PeriodicalId\":736,\"journal\":{\"name\":\"Plasmonics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasmonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://doi.org/10.1007/s11468-024-02401-6\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasmonics","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1007/s11468-024-02401-6","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Versatile Terahertz Metamaterial Sensor for Biomedical Applications
In this work, we propose a THz metamaterial for biomedical applications. The full vectorial finite element method is used to design and analyze the reported biosensor. The proposed sensor is based on increasing the confinement of the electric and magnetic fields at the analyte layer at the resonance frequency. Hence, any slight variation of the optical properties of the analyte sample (typically the refractive index) can be detected. We demonstrate the potential of using the reported sensor for hemoglobin (Hb) concentration and early cancer detection. The geometrical parameters are studied to maximize the sensor sensitivity of the symmetric and asymmetric designs. An absorptivity of 0.98 is achieved at 1.1 THz, which depends on the analyte sample refractive index. High sensor sensitivity of 1.08 GHz/g/dL is obtained with high Q-factor of 13.2 and FWHM (full width at half maximum) of 140 GHz through hemoglobin (Hb) concentration change from 5 g/dL to 20 g/dL. Further, an average sensitivity of 556.325 GHz/RIU is realized for cancer early detection for basal cell, breast cell, Jurkat cell and Cervical cell. Therefore, the proposed design is a good candidate for biomedical applications.
期刊介绍:
Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons.
Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.