用于生物医学应用的多功能太赫兹超材料传感器

IF 3.3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL
Mahmoud Maree E. Tammam, Mohamed Farhat O. Hameed, Essam M. A. Elkaramany, Tamer A. Ali, S. S. A. Obayya
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引用次数: 0

摘要

在这项工作中,我们提出了一种用于生物医学应用的太赫兹超材料。全矢量有限元法用于设计和分析报告中的生物传感器。所提出的传感器是基于在共振频率下增加分析物层的电场和磁场限制。因此,分析样品光学特性(通常是折射率)的任何细微变化都能被检测到。我们展示了将所报告的传感器用于血红蛋白(Hb)浓度和早期癌症检测的潜力。我们对几何参数进行了研究,以最大限度地提高对称和非对称设计的传感器灵敏度。1.1 太赫兹时的吸收率为 0.98,这取决于分析样品的折射率。当血红蛋白(Hb)浓度从 5 g/dL 变化到 20 g/dL 时,传感器灵敏度为 1.08 GHz/g/dL,Q 因子为 13.2,FWHM(半最大值全宽)为 140 GHz。此外,基底细胞、乳腺细胞、Jurkat 细胞和宫颈细胞的癌症早期检测平均灵敏度为 556.325 GHz/RIU。因此,所提出的设计是生物医学应用的良好候选方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Versatile Terahertz Metamaterial Sensor for Biomedical Applications

Versatile Terahertz Metamaterial Sensor for Biomedical Applications

In this work, we propose a THz metamaterial for biomedical applications. The full vectorial finite element method is used to design and analyze the reported biosensor. The proposed sensor is based on increasing the confinement of the electric and magnetic fields at the analyte layer at the resonance frequency. Hence, any slight variation of the optical properties of the analyte sample (typically the refractive index) can be detected. We demonstrate the potential of using the reported sensor for hemoglobin (Hb) concentration and early cancer detection. The geometrical parameters are studied to maximize the sensor sensitivity of the symmetric and asymmetric designs. An absorptivity of 0.98 is achieved at 1.1 THz, which depends on the analyte sample refractive index. High sensor sensitivity of 1.08 GHz/g/dL is obtained with high Q-factor of 13.2 and FWHM (full width at half maximum) of 140 GHz through hemoglobin (Hb) concentration change from 5 g/dL to 20 g/dL. Further, an average sensitivity of 556.325 GHz/RIU is realized for cancer early detection for basal cell, breast cell, Jurkat cell and Cervical cell. Therefore, the proposed design is a good candidate for biomedical applications.

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来源期刊
Plasmonics
Plasmonics 工程技术-材料科学:综合
CiteScore
5.90
自引率
6.70%
发文量
164
审稿时长
2.1 months
期刊介绍: Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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