扩大色氨酸钙流化床造粒工艺的规模

IF 2.9 4区 工程技术 Q2 CHEMISTRY, MULTIDISCIPLINARY
Hyeongseok Han, WooChang Sung, Jun-Woo Kim, Kyochan Kim, DongHyun Lee
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引用次数: 0

摘要

色氨酸在人类和动物营养中的重要性不断推动其需求和市场增长。为了提高色氨酸产品的流动性、体积密度和混合效率等可用性,流化床造粒工艺在利用微生物发酵生产色氨酸的工业化生产中发挥着至关重要的作用。该工艺采用简化的蒸发和造粒方法,可高效生产商业颗粒产品。本研究针对流化床造粒机在色氨酸钙颗粒生产中的放大应用进行了固体流动分析,重点关注固体流动特性、造粒机内的流动机制以及造粒机的设计考虑因素。色氨酸钙颗粒的放大案例表明,中试和工厂规模的气泡流化流动机制相似。然后,确定了使流化床造粒机内细颗粒损失最小化的输送脱离高度,以及确保旋风分离器或袋式过滤器等夹带颗粒回收设备能力的夹带率,从而获得了流化床造粒工艺放大的基本设计数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Scale-Up of Fluidized Bed Granulation Process for Calcium–Tryptophan

A Scale-Up of Fluidized Bed Granulation Process for Calcium–Tryptophan

The importance of tryptophan in both human and animal nutrition continues to drive its demand and market growth. To enhance the usability of tryptophan products, such as flowability, bulk density, and mixing efficiency, the fluidized bed granulation process plays a critical role in the industrial production of tryptophan from microbial fermentation. This process involves a simplified method of evaporation and granulation to efficiently produce commercial granular products. This study conducted a solid flow analysis for scaling up fluidized bed granulators in the manufacturing of calcium–tryptophan granules, focusing on the solid flow characteristics, the flow regime within the granulator, and the granulator's design considerations. The scale-up case for calcium–tryptophan granules revealed that the bubbling fluidization flow regime occurred similarly at both pilot and plant scales. Then, the transport disengaging height to minimize fine particle loss inside the fluidized bed granulator and the entrainment rate to secure the capacity of entrained particle recovery equipment such as cyclones or bag filters were determined to obtain basic design data for scale-up of the fluidized bed granulation process.

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来源期刊
Korean Journal of Chemical Engineering
Korean Journal of Chemical Engineering 工程技术-工程:化工
CiteScore
4.60
自引率
11.10%
发文量
310
审稿时长
4.7 months
期刊介绍: The Korean Journal of Chemical Engineering provides a global forum for the dissemination of research in chemical engineering. The Journal publishes significant research results obtained in the Asia-Pacific region, and simultaneously introduces recent technical progress made in other areas of the world to this region. Submitted research papers must be of potential industrial significance and specifically concerned with chemical engineering. The editors will give preference to papers having a clearly stated practical scope and applicability in the areas of chemical engineering, and to those where new theoretical concepts are supported by new experimental details. The Journal also regularly publishes featured reviews on emerging and industrially important subjects of chemical engineering as well as selected papers presented at international conferences on the subjects.
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